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Analysis of intestinal microbiota in hybrid house mice reveals evolutionary divergence in a vertebrate hologenome

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  • Jun Wang

    (Max Planck Institute for Evolutionary Biology
    Institute for Experimental Medicine, Christian-Albrechts-University of Kiel)

  • Shirin Kalyan

    (Institute of Immunology, Christian-Albrechts University Kiel)

  • Natalie Steck

    (Institute for Experimental Medicine, Christian-Albrechts-University of Kiel)

  • Leslie M. Turner

    (Max Planck Institute for Evolutionary Biology)

  • Bettina Harr

    (Max Planck Institute for Evolutionary Biology)

  • Sven Künzel

    (Max Planck Institute for Evolutionary Biology)

  • Marie Vallier

    (Max Planck Institute for Evolutionary Biology
    Institute for Experimental Medicine, Christian-Albrechts-University of Kiel)

  • Robert Häsler

    (Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel)

  • Andre Franke

    (Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel)

  • Hans-Heinrich Oberg

    (Institute of Immunology, Christian-Albrechts University Kiel)

  • Saleh M. Ibrahim

    (University of Lübeck)

  • Guntram A. Grassl

    (Institute for Experimental Medicine, Christian-Albrechts-University of Kiel)

  • Dieter Kabelitz

    (Institute of Immunology, Christian-Albrechts University Kiel)

  • John F. Baines

    (Max Planck Institute for Evolutionary Biology
    Institute for Experimental Medicine, Christian-Albrechts-University of Kiel)

Abstract

Recent evidence suggests that natural selection operating on hosts to maintain their microbiome contributes to the emergence of new species, that is, the ‘hologenomic basis of speciation’. Here we analyse the gut microbiota of two house mice subspecies, Mus musculus musculus and M. m. domesticus, across their Central European hybrid zone, in addition to hybrids generated in the lab. Hybrid mice display widespread transgressive phenotypes (that is, exceed or fall short of parental values) in a variety of measures of bacterial community structure, which reveals the importance of stabilizing selection operating on the intestinal microbiome within species. Further genetic and immunological analyses reveal genetic incompatibilities, aberrant immune gene expression and increased intestinal pathology associated with altered community structure among hybrids. These results provide unique insight into the consequences of evolutionary divergence in a vertebrate ‘hologenome’, which may be an unrecognized contributing factor to reproductive isolation in this taxonomic group.

Suggested Citation

  • Jun Wang & Shirin Kalyan & Natalie Steck & Leslie M. Turner & Bettina Harr & Sven Künzel & Marie Vallier & Robert Häsler & Andre Franke & Hans-Heinrich Oberg & Saleh M. Ibrahim & Guntram A. Grassl & D, 2015. "Analysis of intestinal microbiota in hybrid house mice reveals evolutionary divergence in a vertebrate hologenome," Nature Communications, Nature, vol. 6(1), pages 1-10, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7440
    DOI: 10.1038/ncomms7440
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