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Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease

Author

Listed:
  • Mohammed Eslam

    (Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney)

  • Ahmed M. Hashem

    (Faculty of Engineering, Minia University)

  • Reynold Leung

    (Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney
    Institute of Immunology and Allergy Research, Westmead Hospital and Westmead Millennium Institute, University of Sydney)

  • Manuel Romero-Gomez

    (Unit for The Clinical Management of Digestive Diseases and CIBERehd, Hospital Universitario de Valme)

  • Thomas Berg

    (Medizinische Klinik m.S. Hepatologie und Gastroenterologie, Charite, Campus Virchow-Klinikum, Universitätsmedizin Berlin
    Clinic for Gastroenterology and Rheumatology, University Clinic Leipzig)

  • Gregory J. Dore

    (Kirby Institute, The University of New South Wales
    St Vincent’s Hospital)

  • Henry L.K. Chan

    (Prince of Wales Hospital, The Chinese University of Hong Kong)

  • William L. Irving

    (NIHR Biomedical Research Unit in Gastroenterology and the Liver, University of Nottingham)

  • David Sheridan

    (Liver Research Group, Institute of Cellular Medicine, Medical School, Newcastle University
    Institute of Translational and Stratified Medicine, Plymouth University)

  • Maria L. Abate

    (University of Turin)

  • Leon A. Adams

    (School of Medicine and Pharmacology, Sir Charles Gairdner Hospital Unit, University of Western Australia)

  • Alessandra Mangia

    (Ospedale Casa Sollievo della Sofferenza, IRCCS)

  • Martin Weltman

    (Nepean Hospital)

  • Elisabetta Bugianesi

    (University of Turin)

  • Ulrich Spengler

    (University of Bonn)

  • Olfat Shaker

    (Faculty of Medicine, Cairo University)

  • Janett Fischer

    (Medizinische Klinik m.S. Hepatologie und Gastroenterologie, Charite, Campus Virchow-Klinikum, Universitätsmedizin Berlin)

  • Lindsay Mollison

    (Fremantle Hospital)

  • Wendy Cheng

    (Royal Perth Hospital)

  • Elizabeth Powell

    (Princess Alexandra Hospital
    The University of Queensland, School of Medicine, Princess Alexandra Hospital)

  • Jacob Nattermann

    (University of Bonn)

  • Stephen Riordan

    (Gastrointestinal and Liver Unit, Prince of Wales Hospital and University of New South Wales)

  • Duncan McLeod

    (Institute of Clinical Pathology and Medical Research (ICPMR), Westmead Hospital)

  • Nicola J. Armstrong

    (School of Mathematics and Statistics, University of Sydney)

  • Mark W. Douglas

    (Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney)

  • Christopher Liddle

    (Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney)

  • David R. Booth

    (Institute of Immunology and Allergy Research, Westmead Hospital and Westmead Millennium Institute, University of Sydney)

  • Jacob George

    (Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney)

  • Golo Ahlenstiel

    (Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney)

Abstract

Tissue fibrosis is a core pathologic process that contributes to mortality in ~45% of the population and is likely to be influenced by the host genetic architecture. Here we demonstrate, using liver disease as a model, that a single-nucleotide polymorphism (rs12979860) in the intronic region of interferon-λ4 (IFNL4) is a strong predictor of fibrosis in an aetiology-independent manner. In a cohort of 4,172 patients, including 3,129 with chronic hepatitis C (CHC), 555 with chronic hepatitis B (CHB) and 488 with non-alcoholic fatty liver disease (NAFLD), those with rs12979860CC have greater hepatic inflammation and fibrosis. In CHC, those with rs12979860CC also have greater stage-constant and stage-specific fibrosis progression rates (P

Suggested Citation

  • Mohammed Eslam & Ahmed M. Hashem & Reynold Leung & Manuel Romero-Gomez & Thomas Berg & Gregory J. Dore & Henry L.K. Chan & William L. Irving & David Sheridan & Maria L. Abate & Leon A. Adams & Alessan, 2015. "Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease," Nature Communications, Nature, vol. 6(1), pages 1-10, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7422
    DOI: 10.1038/ncomms7422
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