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Arabidopsis MSH1 mutation alters the epigenome and produces heritable changes in plant growth

Author

Listed:
  • Kamaldeep S. Virdi

    (School of Biological Sciences, University of Nebraska)

  • John D. Laurie

    (University of Nebraska)

  • Ying-Zhi Xu

    (University of Nebraska)

  • Jiantao Yu

    (University of Nebraska)

  • Mon-Ray Shao

    (University of Nebraska)

  • Robersy Sanchez

    (University of Nebraska)

  • Hardik Kundariya

    (University of Nebraska)

  • Dong Wang

    (University of Nebraska)

  • Jean-Jack M. Riethoven

    (Center for Biotechnology, University of Nebraska)

  • Yashitola Wamboldt

    (University of Nebraska)

  • Maria P. Arrieta-Montiel

    (University of Nebraska)

  • Vikas Shedge

    (University of Nebraska)

  • Sally A. Mackenzie

    (University of Nebraska)

Abstract

Plant phenotypes respond to environmental change, an adaptive capacity that is at least partly transgenerational. However, epigenetic components of this interplay are difficult to measure. Depletion of the nuclear-encoded protein MSH1 causes dramatic and heritable changes in plant development, and here we show that crossing these altered plants with isogenic wild type produces epi-lines with heritable, enhanced growth vigour. Pericentromeric DNA hypermethylation occurs in a subset of msh1 mutants, indicative of heightened transposon repression, while enhanced growth epi-lines show large chromosomal segments of differential CG methylation, reflecting genome-wide reprogramming. When seedlings are treated with 5-azacytidine, root growth of epi-lines is restored to wild-type levels, implicating hypermethylation in enhanced growth. Grafts of wild-type floral stems to mutant rosettes produce progeny with enhanced growth and altered CG methylation strikingly similar to epi-lines, indicating a mobile signal when MSH1 is downregulated, and confirming the programmed nature of methylome and phenotype changes.

Suggested Citation

  • Kamaldeep S. Virdi & John D. Laurie & Ying-Zhi Xu & Jiantao Yu & Mon-Ray Shao & Robersy Sanchez & Hardik Kundariya & Dong Wang & Jean-Jack M. Riethoven & Yashitola Wamboldt & Maria P. Arrieta-Montiel , 2015. "Arabidopsis MSH1 mutation alters the epigenome and produces heritable changes in plant growth," Nature Communications, Nature, vol. 6(1), pages 1-9, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7386
    DOI: 10.1038/ncomms7386
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