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In vivo odourant response properties of migrating adult-born neurons in the mouse olfactory bulb

Author

Listed:
  • Yury Kovalchuk

    (Institute of Physiology II, University of Tübingen, Keplerstrasse 15, 72074 Tübingen, Germany)

  • Ryota Homma

    (Yale University)

  • Yajie Liang

    (Institute of Physiology II, University of Tübingen, Keplerstrasse 15, 72074 Tübingen, Germany)

  • Anatoliy Maslyukov

    (Institute of Physiology II, University of Tübingen, Keplerstrasse 15, 72074 Tübingen, Germany)

  • Marina Hermes

    (Institute of Physiology II, University of Tübingen, Keplerstrasse 15, 72074 Tübingen, Germany)

  • Thomas Thestrup

    (Max Planck Institute of Neurobiology)

  • Oliver Griesbeck

    (Max Planck Institute of Neurobiology)

  • Jovica Ninkovic

    (Helmholtz Zentrum München, Institute of Stem Cell Research)

  • Lawrence B. Cohen

    (Yale University
    Center for Functional Connectomics, Korea Institute of Science and Technology)

  • Olga Garaschuk

    (Institute of Physiology II, University of Tübingen, Keplerstrasse 15, 72074 Tübingen, Germany)

Abstract

Juxtaglomerular neurons (JGNs) of the mammalian olfactory bulb are generated throughout life. Their integration into the preexisting neural network, their differentiation and survival therein depend on sensory activity, but when and how these adult-born cells acquire responsiveness to sensory stimuli remains unknown. In vivo two-photon imaging of retrovirally labelled adult-born JGNs reveals that ~90% of the cells arrive at the glomerular layer after day post injection (DPI) 7. After arrival, adult-born JGNs are still migrating, but at DPI 9, 52% of them have odour-evoked Ca2+ signals. Their odourant sensitivity closely resembles that of the parent glomerulus and surrounding JGNs, and their spontaneous and odour-evoked spiking is similar to that of their resident neighbours. Our data reveal a remarkably rapid functional integration of adult-born cells into the preexisting neural network. The mature pattern of odour-evoked responses of these cells strongly contrasts with their molecular phenotype, which is typical of immature, migrating neuroblasts.

Suggested Citation

  • Yury Kovalchuk & Ryota Homma & Yajie Liang & Anatoliy Maslyukov & Marina Hermes & Thomas Thestrup & Oliver Griesbeck & Jovica Ninkovic & Lawrence B. Cohen & Olga Garaschuk, 2015. "In vivo odourant response properties of migrating adult-born neurons in the mouse olfactory bulb," Nature Communications, Nature, vol. 6(1), pages 1-12, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7349
    DOI: 10.1038/ncomms7349
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