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Genetic blueprint of the zoonotic pathogen Toxocara canis

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  • Xing-Quan Zhu

    (State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences
    Faculty of Veterinary and Agricultural Sciences, The University of Melbourne)

  • Pasi K. Korhonen

    (Faculty of Veterinary and Agricultural Sciences, The University of Melbourne)

  • Huimin Cai

    (BGI)

  • Neil D. Young

    (Faculty of Veterinary and Agricultural Sciences, The University of Melbourne)

  • Peter Nejsum

    (University of Copenhagen)

  • Georg von Samson-Himmelstjerna

    (Institute for Parasitology und Tropical Veterinary Medicine, Freie Universität Berlin)

  • Peter R. Boag

    (Monash University)

  • Patrick Tan

    (Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School
    Genome Institute of Singapore)

  • Qiye Li

    (BGI)

  • Jiumeng Min

    (BGI)

  • Yulan Yang

    (BGI)

  • Xiuhua Wang

    (BGI)

  • Xiaodong Fang

    (BGI)

  • Ross S. Hall

    (Faculty of Veterinary and Agricultural Sciences, The University of Melbourne)

  • Andreas Hofmann

    (Structural Chemistry Program, Eskitis Institute, Griffith University)

  • Paul W. Sternberg

    (HHMI, California Institute of Technology)

  • Aaron R. Jex

    (Faculty of Veterinary and Agricultural Sciences, The University of Melbourne)

  • Robin B. Gasser

    (Faculty of Veterinary and Agricultural Sciences, The University of Melbourne)

Abstract

Toxocara canis is a zoonotic parasite of major socioeconomic importance worldwide. In humans, this nematode causes disease (toxocariasis) mainly in the under-privileged communities in developed and developing countries. Although relatively well studied from clinical and epidemiological perspectives, to date, there has been no global investigation of the molecular biology of this parasite. Here we use next-generation sequencing to produce a draft genome and transcriptome of T. canis to support future biological and biotechnological investigations. This genome is 317 Mb in size, has a repeat content of 13.5% and encodes at least 18,596 protein-coding genes. We study transcription in a larval, as well as adult female and male stages, characterize the parasite’s gene-silencing machinery, explore molecules involved in development or host–parasite interactions and predict intervention targets. The draft genome of T. canis should provide a useful resource for future molecular studies of this and other, related parasites.

Suggested Citation

  • Xing-Quan Zhu & Pasi K. Korhonen & Huimin Cai & Neil D. Young & Peter Nejsum & Georg von Samson-Himmelstjerna & Peter R. Boag & Patrick Tan & Qiye Li & Jiumeng Min & Yulan Yang & Xiuhua Wang & Xiaodon, 2015. "Genetic blueprint of the zoonotic pathogen Toxocara canis," Nature Communications, Nature, vol. 6(1), pages 1-8, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7145
    DOI: 10.1038/ncomms7145
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