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Vaginal type-II mucosa is an inductive site for primary CD8+ T-cell mucosal immunity

Author

Listed:
  • Yichuan Wang

    (Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health)

  • Yongjun Sui

    (Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health)

  • Shingo Kato

    (Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health)

  • Alison E. Hogg

    (Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health
    Aeras, 1405 Research Boulevard)

  • Jason C. Steel

    (The University of Queensland
    Gallipoli Medical Research Foundation)

  • John C. Morris

    (University of Cincinnati Cancer Institute)

  • Jay A. Berzofsky

    (Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health)

Abstract

The structured lymphoid tissues are considered the only inductive sites where primary T-cell immune responses occur. The naïve T cells in structured lymphoid tissues, once being primed by antigen-bearing dendritic cells, differentiate into memory T cells and traffic back to the mucosal sites through the bloodstream. Contrary to this belief, here we show that the vaginal type-II mucosa itself, despite the lack of structured lymphoid tissues, can act as an inductive site during primary CD8+ T-cell immune responses. We provide evidence that the vaginal mucosa supports both the local immune priming of naïve CD8+ T cells and the local expansion of antigen-specific CD8+ T cells, thereby demonstrating a different paradigm for primary mucosal T-cell immune induction.

Suggested Citation

  • Yichuan Wang & Yongjun Sui & Shingo Kato & Alison E. Hogg & Jason C. Steel & John C. Morris & Jay A. Berzofsky, 2015. "Vaginal type-II mucosa is an inductive site for primary CD8+ T-cell mucosal immunity," Nature Communications, Nature, vol. 6(1), pages 1-13, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7100
    DOI: 10.1038/ncomms7100
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