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Substrate stiffness-modulated registry phase correlations in cardiomyocytes map structural order to coherent beating

Author

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  • K. Dasbiswas

    (Weizmann Institute of Science)

  • S. Majkut

    (University of Pennsylvania
    Physics and Astronomy Graduate Group, University of Pennsylvania)

  • D. E. Discher

    (University of Pennsylvania
    Physics and Astronomy Graduate Group, University of Pennsylvania
    Cell and Molecular Biology Graduate Group, University of Pennsylvania)

  • Samuel A. Safran

    (Weizmann Institute of Science)

Abstract

Recent experiments show that both striation, an indication of the structural registry in muscle fibres, as well as the contractile strains produced by beating cardiac muscle cells can be optimized by substrate stiffness. Here we show theoretically how the substrate rigidity dependence of the registry data can be mapped onto that of the strain measurements. We express the elasticity-mediated structural registry as a phase-order parameter using a statistical physics approach that takes the noise and disorder inherent in biological systems into account. By assuming that structurally registered myofibrils also tend to beat in phase, we explain the observed dependence of both striation and strain measurements of cardiomyocytes on substrate stiffness in a unified manner. The agreement of our ideas with experiment suggests that the correlated beating of heart cells may be limited by the structural order of the myofibrils, which in turn is regulated by their elastic environment.

Suggested Citation

  • K. Dasbiswas & S. Majkut & D. E. Discher & Samuel A. Safran, 2015. "Substrate stiffness-modulated registry phase correlations in cardiomyocytes map structural order to coherent beating," Nature Communications, Nature, vol. 6(1), pages 1-8, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7085
    DOI: 10.1038/ncomms7085
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