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Different forms of effective connectivity in primate frontotemporal pathways

Author

Listed:
  • Christopher I. Petkov

    (Institute of Neuroscience, Framlington Place, Newcastle University
    Max Planck Institute for Biological Cybernetics)

  • Yukiko Kikuchi

    (Institute of Neuroscience, Framlington Place, Newcastle University
    Laboratory of Neuropsychology, NIMH, NIH
    Georgetown University Medical Center)

  • Alice E. Milne

    (Institute of Neuroscience, Framlington Place, Newcastle University)

  • Mortimer Mishkin

    (Laboratory of Neuropsychology, NIMH, NIH)

  • Josef P. Rauschecker

    (Georgetown University Medical Center
    Institute for Advanced Study, Technische Universität München)

  • Nikos K. Logothetis

    (Max Planck Institute for Biological Cybernetics
    University of Manchester, Stopford Building)

Abstract

It is generally held that non-primary sensory regions of the brain have a strong impact on frontal cortex. However, the effective connectivity of pathways to frontal cortex is poorly understood. Here we microstimulate sites in the superior temporal and ventral frontal cortex of monkeys and use functional magnetic resonance imaging to evaluate the functional activity resulting from the stimulation of interconnected regions. Surprisingly, we find that, although certain earlier stages of auditory cortical processing can strongly activate frontal cortex, downstream auditory regions, such as voice-sensitive cortex, appear to functionally engage primarily an ipsilateral temporal lobe network. Stimulating other sites within this activated temporal lobe network shows strong activation of frontal cortex. The results indicate that the relative stage of sensory processing does not predict the level of functional access to the frontal lobes. Rather, certain brain regions engage local networks, only parts of which have a strong functional impact on frontal cortex.

Suggested Citation

  • Christopher I. Petkov & Yukiko Kikuchi & Alice E. Milne & Mortimer Mishkin & Josef P. Rauschecker & Nikos K. Logothetis, 2015. "Different forms of effective connectivity in primate frontotemporal pathways," Nature Communications, Nature, vol. 6(1), pages 1-13, May.
  • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7000
    DOI: 10.1038/ncomms7000
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