IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v6y2015i1d10.1038_ncomms6998.html
   My bibliography  Save this article

Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids

Author

Listed:
  • Michael E. Kurczy

    (Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute)

  • Zheng-Jiang Zhu

    (Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute)

  • Julijana Ivanisevic

    (Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute)

  • Adam M. Schuyler

    (Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute)

  • Kush Lalwani

    (Pfizer Worldwide Research and Development)

  • Antonio F. Santidrian

    (The Scripps Research Institute)

  • John M. David

    (Pfizer Worldwide Research and Development)

  • Anand Giddabasappa

    (Pfizer Worldwide Research and Development)

  • Amanda J. Roberts

    (The Scripps Research Institute)

  • Hernando J. Olivos

    (Waters Corporation, 100 Cummings Center)

  • Peter J. O’Brien

    (Pfizer Worldwide Research and Development)

  • Lauren Franco

    (Montana State University)

  • Matthew W. Fields

    (Montana State University)

  • Liliana P. Paris

    (The Scripps Research Institute)

  • Martin Friedlander

    (The Scripps Research Institute)

  • Caroline H. Johnson

    (Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute)

  • Adrian A. Epstein

    (University of Nebraska Medical Center)

  • Howard E. Gendelman

    (University of Nebraska Medical Center)

  • Malcolm R. Wood

    (The Core Microscopy Facility, The Scripps Research Institute)

  • Brunhilde H. Felding

    (The Scripps Research Institute)

  • Gary J. Patti

    (Washington University in St. Louis, One Brookings Drive
    Washington University School of Medicine)

  • Mary E. Spilker

    (Pfizer Worldwide Research and Development)

  • Gary Siuzdak

    (Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute
    Molecular and Computational Biology, The Scripps Research Institute)

Abstract

Fluorocarbons are lipophobic and non-polar molecules that exhibit remarkable biocompatibility, with applications in liquid ventilation and synthetic blood. The unique properties of these compounds have also enabled mass spectrometry imaging of tissues where the fluorocarbons act as a Teflon-like coating for nanostructured surfaces to assist in desorption/ionization. Here we report fluorinated gold nanoparticles (f-AuNPs) designed to facilitate nanostructure imaging mass spectrometry. Irradiation of f-AuNPs results in the release of the fluorocarbon ligands providing a driving force for analyte desorption. The f-AuNPs allow for the mass spectrometry analysis of both lipophilic and polar (central carbon) metabolites. An important property of AuNPs is that they also act as contrast agents for X-ray microtomography and electron microscopy, a feature we have exploited by infusing f-AuNPs into tissue via fluorocarbon liquids to facilitate multimodal (molecular and anatomical) imaging.

Suggested Citation

  • Michael E. Kurczy & Zheng-Jiang Zhu & Julijana Ivanisevic & Adam M. Schuyler & Kush Lalwani & Antonio F. Santidrian & John M. David & Anand Giddabasappa & Amanda J. Roberts & Hernando J. Olivos & Pete, 2015. "Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids," Nature Communications, Nature, vol. 6(1), pages 1-8, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms6998
    DOI: 10.1038/ncomms6998
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms6998
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms6998?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms6998. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.