IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v6y2015i1d10.1038_ncomms6988.html
   My bibliography  Save this article

Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor

Author

Listed:
  • Ying Liu

    (CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences (CAS))

  • Chunying Chen

    (CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences (CAS))

  • Pengxu Qian

    (Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China)

  • Xuefei Lu

    (Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China)

  • Baoyun Sun

    (CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences (CAS))

  • Xiao Zhang

    (Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China)

  • Liming Wang

    (CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences (CAS))

  • Xingfa Gao

    (CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences (CAS))

  • Han Li

    (CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences (CAS))

  • Zhiyun Chen

    (CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences (CAS))

  • Jinglong Tang

    (CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences (CAS))

  • Weijie Zhang

    (Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China)

  • Jinquan Dong

    (CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences (CAS))

  • Ru Bai

    (CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences (CAS))

  • Peter E. Lobie

    (Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China
    National University of Singapore)

  • Qingfa Wu

    (Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China)

  • Suling Liu

    (Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China)

  • Huafeng Zhang

    (Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China)

  • Feng Zhao

    (CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences (CAS))

  • Max S. Wicha

    (Comprehensive Cancer Center, University of Michigan)

  • Tao Zhu

    (Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China)

  • Yuliang Zhao

    (CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences (CAS))

Abstract

The contemporary use of nanomedicines for cancer treatment has been largely limited to serving as carriers for existing therapeutic agents. Here, we provide definitive evidence that, the metallofullerenol nanomaterial Gd@C82(OH)22, while essentially not toxic to normal mammary epithelial cells, possesses intrinsic inhibitory activity against triple-negative breast cancer cells. Gd@C82(OH)22 blocks epithelial-to-mesenchymal transition with resultant efficient elimination of breast cancer stem cells (CSCs) resulting in abrogation of tumour initiation and metastasis. In normoxic conditions, Gd@C82(OH)22 mediates these effects by blocking TGF-β signalling. Moreover, under hypoxic conditions found in the tumour microenvironment, cellular uptake of Gd@C82(OH)22 is facilitated where it functions as a bi-potent inhibitor of HIF-1α and TGF-β activities, enhancing CSC elimination. These studies indicate that nanomaterials can be engineered to directly target CSCs. Thus, Gd-metallofullerenol is identified as a kind of non-toxic CSC specific inhibitors with significant therapeutic potential.

Suggested Citation

  • Ying Liu & Chunying Chen & Pengxu Qian & Xuefei Lu & Baoyun Sun & Xiao Zhang & Liming Wang & Xingfa Gao & Han Li & Zhiyun Chen & Jinglong Tang & Weijie Zhang & Jinquan Dong & Ru Bai & Peter E. Lobie &, 2015. "Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor," Nature Communications, Nature, vol. 6(1), pages 1-18, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms6988
    DOI: 10.1038/ncomms6988
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms6988
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms6988?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms6988. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.