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Revisiting the role of histo-blood group antigens in rotavirus host-cell invasion

Author

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  • Raphael Böhm

    (Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia)

  • Fiona E. Fleming

    (The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Andrea Maggioni

    (Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia)

  • Vi T. Dang

    (The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Gavan Holloway

    (The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Barbara S. Coulson

    (The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Mark von Itzstein

    (Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia)

  • Thomas Haselhorst

    (Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia)

Abstract

Histo-blood group antigens (HBGAs) have been proposed as rotavirus receptors. H type-1 and Lewisb antigens have been reported to bind VP8* from major human rotavirus genotypes P[4], P[6] and P[8], while VP8* from a rarer P[14] rotavirus recognizes A-type HBGAs. However, the role and significance of HBGA receptors in rotavirus pathogenesis remains uncertain. Here we report that P[14] rotavirus HAL1166 and the related P[9] human rotavirus K8 bind to A-type HBGAs, although neither virus engages the HBGA-specific α1,2-linked fucose moiety. Notably, human rotaviruses DS-1 (P[4]) and RV-3 (P[6]) also use A-type HBGAs for infection, with fucose involvement. However, human P[8] rotavirus Wa does not recognize A-type HBGAs. Furthermore, the common human rotaviruses that we have investigated do not use Lewisb and H type-1 antigens. Our results indicate that A-type HBGAs are receptors for human rotaviruses, although rotavirus strains vary in their ability to recognize these antigens.

Suggested Citation

  • Raphael Böhm & Fiona E. Fleming & Andrea Maggioni & Vi T. Dang & Gavan Holloway & Barbara S. Coulson & Mark von Itzstein & Thomas Haselhorst, 2015. "Revisiting the role of histo-blood group antigens in rotavirus host-cell invasion," Nature Communications, Nature, vol. 6(1), pages 1-12, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms6907
    DOI: 10.1038/ncomms6907
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