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CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes

Author

Listed:
  • Emma C. Mackley

    (MRC Centre for Immune Regulation, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham)

  • Stephanie Houston

    (Institute of Infection, Immunity and Inflammation, University of Glasgow)

  • Clare L. Marriott

    (MRC Centre for Immune Regulation, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham)

  • Emily E. Halford

    (MRC Centre for Immune Regulation, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham)

  • Beth Lucas

    (MRC Centre for Immune Regulation, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham)

  • Vuk Cerovic

    (Institute of Infection, Immunity and Inflammation, University of Glasgow)

  • Kara J. Filbey

    (Institute of Immunology and Infection Research, University of Edinburgh)

  • Rick M. Maizels

    (Institute of Immunology and Infection Research, University of Edinburgh)

  • Matthew R. Hepworth

    (Division of Gastroenterology, Joan and Sanford I. Weill Department of Medicine
    The Jill Robert’s Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medical College)

  • Gregory F. Sonnenberg

    (Division of Gastroenterology, Joan and Sanford I. Weill Department of Medicine
    The Jill Robert’s Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medical College
    The Jill Robert's Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medical College)

  • Simon Milling

    (Institute of Infection, Immunity and Inflammation, University of Glasgow)

  • David R. Withers

    (MRC Centre for Immune Regulation, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham)

Abstract

Presentation of peptide:MHCII by RORγ-expressing group 3 innate lymphoid cells (ILC3s), which are enriched within gut tissue, is required for control of CD4 T-cell responses to commensal bacteria. It is not known whether ILC populations migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues. Here we demonstrate that ILC3s reside within the interfollicular areas of mucosal draining lymph nodes, forming a distinct microenvironment not observed in peripheral lymph nodes. By photoconverting intestinal cells in Kaede mice we reveal constitutive trafficking of ILCs from the intestine to the draining mesenteric lymph nodes, which specifically for the LTi-like ILC3s was CCR7-dependent. Thus, ILC populations traffic to draining lymph nodes using different mechanisms.

Suggested Citation

  • Emma C. Mackley & Stephanie Houston & Clare L. Marriott & Emily E. Halford & Beth Lucas & Vuk Cerovic & Kara J. Filbey & Rick M. Maizels & Matthew R. Hepworth & Gregory F. Sonnenberg & Simon Milling &, 2015. "CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes," Nature Communications, Nature, vol. 6(1), pages 1-13, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms6862
    DOI: 10.1038/ncomms6862
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