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Paternal heterochromatin formation in human embryos is H3K9/HP1 directed and primed by sperm-derived histone modifications

Author

Listed:
  • Christine van de Werken

    (Erasmus MC, University Medical Center)

  • Godfried W. van der Heijden

    (Erasmus MC, University Medical Center
    Erasmus MC, University Medical Center)

  • Cindy Eleveld

    (Erasmus MC, University Medical Center)

  • Miriam Teeuwssen

    (Erasmus MC, University Medical Center)

  • Mareike Albert

    (Friedrich Miescher Institute for Biomedical Research
    Present address: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany)

  • Willy M. Baarends

    (Erasmus MC, University Medical Center)

  • Joop S. E. Laven

    (Erasmus MC, University Medical Center)

  • Antoine H. F. M. Peters

    (Friedrich Miescher Institute for Biomedical Research
    Faculty of Sciences, University of Basel)

  • Esther B. Baart

    (Erasmus MC, University Medical Center)

Abstract

The different configurations of maternal and paternal chromatin, acquired during oogenesis and spermatogenesis, have to be rearranged after fertilization to form a functional embryonic genome. In the paternal genome, nucleosomal chromatin domains are re-established after the protamine-to-histone exchange. We investigated the formation of constitutive heterochromatin (cHC) in human preimplantation embryos. Our results show that histones carrying canonical cHC modifications are retained in cHC regions of sperm chromatin. These modified histones are transmitted to the oocyte and contribute to the formation of paternal embryonic cHC. Subsequently, the modifications are recognized by the H3K9/HP1 pathway maternal chromatin modifiers and propagated over the embryonic cleavage divisions. These results are in contrast to what has been described for mouse embryos, in which paternal cHC lacks canonical modifications and is initially established by Polycomb group proteins. Our results show intergenerational epigenetic inheritance of the cHC structure in human embryos.

Suggested Citation

  • Christine van de Werken & Godfried W. van der Heijden & Cindy Eleveld & Miriam Teeuwssen & Mareike Albert & Willy M. Baarends & Joop S. E. Laven & Antoine H. F. M. Peters & Esther B. Baart, 2014. "Paternal heterochromatin formation in human embryos is H3K9/HP1 directed and primed by sperm-derived histone modifications," Nature Communications, Nature, vol. 5(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6868
    DOI: 10.1038/ncomms6868
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