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Functionally reciprocal mutations of the prolactin signalling pathway define hairy and slick cattle

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  • Mathew D. Littlejohn

    (Livestock Improvement Corporation, Cnr Ruakura and Morrinsville Roads
    School of Biological Sciences, University of Auckland)

  • Kristen M. Henty

    (School of Biological Sciences, University of Auckland)

  • Kathryn Tiplady

    (Livestock Improvement Corporation, Cnr Ruakura and Morrinsville Roads)

  • Thomas Johnson

    (Livestock Improvement Corporation, Cnr Ruakura and Morrinsville Roads)

  • Chad Harland

    (Livestock Improvement Corporation, Cnr Ruakura and Morrinsville Roads)

  • Thomas Lopdell

    (Livestock Improvement Corporation, Cnr Ruakura and Morrinsville Roads)

  • Richard G. Sherlock

    (Livestock Improvement Corporation, Cnr Ruakura and Morrinsville Roads)

  • Wanbo Li

    (Unit of Animal Genomics, GIGA-R, Faculty of Veterinary Medicine, University of Liège (B34))

  • Steven D. Lukefahr

    (Rangeland and Wildlife Sciences, Texas A&M University-Kingsville, MSC 228, Kingsville, Texas 78363-8202, USA)

  • Bruce C. Shanks

    (Lincoln University)

  • Dorian J. Garrick

    (Iowa State University)

  • Russell G. Snell

    (School of Biological Sciences, University of Auckland)

  • Richard J. Spelman

    (Livestock Improvement Corporation, Cnr Ruakura and Morrinsville Roads)

  • Stephen R. Davis

    (Livestock Improvement Corporation, Cnr Ruakura and Morrinsville Roads)

Abstract

Lactation, hair development and homeothermy are characteristic evolutionary features that define mammals from other vertebrate species. Here we describe the discovery of two autosomal dominant mutations with antagonistic, pleiotropic effects on all three of these biological processes, mediated through the prolactin signalling pathway. Most conspicuously, mutations in prolactin (PRL) and its receptor (PRLR) have an impact on thermoregulation and hair morphology phenotypes, giving prominence to this pathway outside of its classical roles in lactation.

Suggested Citation

  • Mathew D. Littlejohn & Kristen M. Henty & Kathryn Tiplady & Thomas Johnson & Chad Harland & Thomas Lopdell & Richard G. Sherlock & Wanbo Li & Steven D. Lukefahr & Bruce C. Shanks & Dorian J. Garrick &, 2014. "Functionally reciprocal mutations of the prolactin signalling pathway define hairy and slick cattle," Nature Communications, Nature, vol. 5(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6861
    DOI: 10.1038/ncomms6861
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