IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v5y2014i1d10.1038_ncomms6780.html
   My bibliography  Save this article

Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation

Author

Listed:
  • Qingtian Li

    (Center for Inflammation and Epigenetics, Houston Methodist Research Institute)

  • Jia Zou

    (Center for Inflammation and Epigenetics, Houston Methodist Research Institute)

  • Mingjun Wang

    (Center for Inflammation and Epigenetics, Houston Methodist Research Institute)

  • Xilai Ding

    (Center for Inflammation and Epigenetics, Houston Methodist Research Institute)

  • Iouri Chepelev

    (Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center)

  • Xikun Zhou

    (Center for Inflammation and Epigenetics, Houston Methodist Research Institute)

  • Wei Zhao

    (Center for Inflammation and Epigenetics, Houston Methodist Research Institute)

  • Gang Wei

    (CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences)

  • Jun Cui

    (Center for Inflammation and Epigenetics, Houston Methodist Research Institute)

  • Keji Zhao

    (Systems Biology Center, National Heart, Lung, and Blood Institute, NIH)

  • Helen Y. Wang

    (Center for Inflammation and Epigenetics, Houston Methodist Research Institute)

  • Rong-Fu Wang

    (Center for Inflammation and Epigenetics, Houston Methodist Research Institute)

Abstract

Epigenetic factors have been implicated in the regulation of CD4+ T-cell differentiation. Jmjd3 plays a role in many biological processes, but its in vivo function in T-cell differentiation remains unknown. Here we report that Jmjd3 ablation promotes CD4+ T-cell differentiation into Th2 and Th17 cells in the small intestine and colon, and inhibits T-cell differentiation into Th1 cells under different cytokine-polarizing conditions and in a Th1-dependent colitis model. Jmjd3 deficiency also restrains the plasticity of the conversion of Th2, Th17 or Treg cells to Th1 cells. The skewing of T-cell differentiation is concomitant with changes in the expression of key transcription factors and cytokines. H3K27me3 and H3K4me3 levels in Jmjd3-deficient cells are correlated with altered gene expression through interactions with specific transcription factors. Our results identify Jmjd3 as an epigenetic factor in T-cell differentiation via changes in histone methylation and target gene expression.

Suggested Citation

  • Qingtian Li & Jia Zou & Mingjun Wang & Xilai Ding & Iouri Chepelev & Xikun Zhou & Wei Zhao & Gang Wei & Jun Cui & Keji Zhao & Helen Y. Wang & Rong-Fu Wang, 2014. "Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation," Nature Communications, Nature, vol. 5(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6780
    DOI: 10.1038/ncomms6780
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms6780
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms6780?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6780. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.