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Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation

Author

Listed:
  • Liang Sun

    (University of Warwick)

  • Anaïs Pitto-Barry

    (University of Warwick)

  • Nigel Kirby

    (Australian Synchrotron)

  • Tara L. Schiller

    (Monash University, Clayton
    School of Science and Technology, University of New England)

  • Ana M. Sanchez

    (University of Warwick)

  • M. Adam Dyson

    (University of Warwick)

  • Jeremy Sloan

    (University of Warwick)

  • Neil R. Wilson

    (University of Warwick)

  • Rachel K. O’Reilly

    (University of Warwick)

  • Andrew P. Dove

    (University of Warwick
    Monash University, Clayton)

Abstract

Co-crystallization of polymers with different configurations/tacticities provides access to materials with enhanced performance. The stereocomplexation of isotactic poly(L-lactide) and poly(D-lactide) has led to improved properties compared with each homochiral material. Herein, we report the preparation of stereocomplex micelles from a mixture of poly(L-lactide)-b-poly(acrylic acid) and poly(D-lactide)-b-poly(acrylic acid) diblock copolymers in water via crystallization-driven self-assembly. During the formation of these stereocomplex micelles, an unexpected morphological transition results in the formation of dense crystalline spherical micelles rather than cylinders. Furthermore, mixture of cylinders with opposite homochirality in either THF/H2O mixtures or in pure water at 65 °C leads to disassembly into stereocomplexed spherical micelles. Similarly, a transition is also observed in a related PEO-b-PLLA/PEO-b-PDLA system, demonstrating wider applicability. This new mechanism for morphological reorganization, through competitive crystallization and stereocomplexation and without the requirement for an external stimulus, allows for new opportunities in controlled release and delivery applications.

Suggested Citation

  • Liang Sun & Anaïs Pitto-Barry & Nigel Kirby & Tara L. Schiller & Ana M. Sanchez & M. Adam Dyson & Jeremy Sloan & Neil R. Wilson & Rachel K. O’Reilly & Andrew P. Dove, 2014. "Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation," Nature Communications, Nature, vol. 5(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6746
    DOI: 10.1038/ncomms6746
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