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Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue

Author

Listed:
  • Sava Sakadžić

    (MHG/MIT/HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School)

  • Emiri T. Mandeville

    (Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School)

  • Louis Gagnon

    (MHG/MIT/HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School
    École Polytechnique de Montréal)

  • Joseph J. Musacchia

    (MHG/MIT/HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School)

  • Mohammad A. Yaseen

    (MHG/MIT/HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School)

  • Meryem A. Yucel

    (MHG/MIT/HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School)

  • Joel Lefebvre

    (École Polytechnique de Montréal)

  • Frédéric Lesage

    (École Polytechnique de Montréal)

  • Anders M. Dale

    (University of California San Diego, La Jolla, San Diego, California 92093, USA)

  • Katharina Eikermann-Haerter

    (Neurovascular Research Laboratory, Massachusetts General Hospital and Harvard Medical School)

  • Cenk Ayata

    (Neurovascular Research Laboratory, Massachusetts General Hospital and Harvard Medical School
    Stroke Service and Neuroscience Intensive Care Unit, Massachusetts General Hospital and Harvard Medical School)

  • Vivek J. Srinivasan

    (MHG/MIT/HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School
    Present address: Department of Biomedical Engineering, University of California Davis, Davis, California 95616, USA)

  • Eng H. Lo

    (Neuroprotection Research Laboratory, Massachusetts General Hospital and Harvard Medical School)

  • Anna Devor

    (MHG/MIT/HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School
    University of California San Diego, La Jolla, San Diego, California 92093, USA)

  • David A. Boas

    (MHG/MIT/HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School)

Abstract

What is the organization of cerebral microvascular oxygenation and morphology that allows adequate tissue oxygenation at different activity levels? We address this question in the mouse cerebral cortex using microscopic imaging of intravascular O2 partial pressure and blood flow combined with numerical modelling. Here we show that parenchymal arterioles are responsible for 50% of the extracted O2 at baseline activity, and the majority of the remaining O2 exchange takes place within the first few capillary branches. Most capillaries release little O2 at baseline acting as an O2 reserve that is recruited during increased neuronal activity or decreased blood flow. Our results challenge the common perception that capillaries are the major site of O2 delivery to cerebral tissue. The understanding of oxygenation distribution along arterio-capillary paths may have profound implications for the interpretation of blood-oxygen-level dependent (BOLD) contrast in functional magnetic resonance imaging and for evaluating microvascular O2 delivery capacity to support cerebral tissue in disease.

Suggested Citation

  • Sava Sakadžić & Emiri T. Mandeville & Louis Gagnon & Joseph J. Musacchia & Mohammad A. Yaseen & Meryem A. Yucel & Joel Lefebvre & Frédéric Lesage & Anders M. Dale & Katharina Eikermann-Haerter & Cenk , 2014. "Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue," Nature Communications, Nature, vol. 5(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6734
    DOI: 10.1038/ncomms6734
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