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Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex

Author

Listed:
  • Benedetta Arnò

    (Neuroimmunology Unit, Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute)

  • Francesca Grassivaro

    (Neuroimmunology Unit, Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute)

  • Chiara Rossi

    (Neuroimmunology Unit, Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute)

  • Andrea Bergamaschi

    (Neuroimmunology Unit, Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute)

  • Valentina Castiglioni

    (University of Milan)

  • Roberto Furlan

    (Neuroimmunology Unit, Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute)

  • Melanie Greter

    (Institute of Experimental Immunology, University of Zurich)

  • Rebecca Favaro

    (University Milano-Bicocca)

  • Giancarlo Comi

    (Institute of Experimental Neurology (INSPE), Vita Salute San Raffaele University)

  • Burkhard Becher

    (Institute of Experimental Immunology, University of Zurich)

  • Gianvito Martino

    (Neuroimmunology Unit, Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute)

  • Luca Muzio

    (Neuroimmunology Unit, Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute)

Abstract

Microglia are observed in the early developing forebrain and contribute to the regulation of neurogenesis through still unravelled mechanisms. In the developing cerebral cortex, microglia cluster in the ventricular/subventricular zone (VZ/SVZ), a region containing Cxcl12-expressing basal progenitors (BPs). Here we show that the ablation of BP as well as genetic loss of Cxcl12 affect microglia recruitment into the SVZ. Ectopic Cxcl12 expression or pharmacological blockage of CxcR4 further supports that Cxcl12/CxcR4 signalling is involved in microglial recruitment during cortical development. Furthermore, we found that cell death in the developing forebrain triggers microglial proliferation and that this is mediated by the release of macrophage migration inhibitory factor (MIF). Finally, we show that the depletion of microglia in mice lacking receptor for colony-stimulating factor–1 (Csf-1R) reduces BPs into the cerebral cortex.

Suggested Citation

  • Benedetta Arnò & Francesca Grassivaro & Chiara Rossi & Andrea Bergamaschi & Valentina Castiglioni & Roberto Furlan & Melanie Greter & Rebecca Favaro & Giancarlo Comi & Burkhard Becher & Gianvito Marti, 2014. "Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex," Nature Communications, Nature, vol. 5(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6611
    DOI: 10.1038/ncomms6611
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