Author
Listed:
- Xinxin You
(Shenzhen Key Lab of Marine Genomics, State Key Laboratory of Agricultural Genomics
BGI-Shenzhen)
- Chao Bian
(Shenzhen Key Lab of Marine Genomics, State Key Laboratory of Agricultural Genomics
BGI-Shenzhen)
- Qijie Zan
(Shenzhen Wild Animal Rescue Center)
- Xun Xu
(BGI-Shenzhen)
- Xin Liu
(BGI-Shenzhen)
- Jieming Chen
(Shenzhen Key Lab of Marine Genomics, State Key Laboratory of Agricultural Genomics
BGI-Shenzhen)
- Jintu Wang
(BGI-Shenzhen)
- Ying Qiu
(Shenzhen Key Lab of Marine Genomics, State Key Laboratory of Agricultural Genomics
BGI-Shenzhen)
- Wujiao Li
(Shenzhen Key Lab of Marine Genomics, State Key Laboratory of Agricultural Genomics)
- Xinhui Zhang
(Shenzhen Key Lab of Marine Genomics, State Key Laboratory of Agricultural Genomics
BGI-Shenzhen)
- Ying Sun
(BGI-Shenzhen)
- Shixi Chen
(College of Ocean and Earth Science, Xiamen University)
- Wanshu Hong
(College of Ocean and Earth Science, Xiamen University)
- Yuxiang Li
(BGI-Shenzhen)
- Shifeng Cheng
(BGI-Shenzhen)
- Guangyi Fan
(BGI-Shenzhen)
- Chengcheng Shi
(BGI-Shenzhen)
- Jie Liang
(BGI-Shenzhen)
- Y. Tom Tang
(BGI-Shenzhen)
- Chengye Yang
(BGI-Shenzhen)
- Zhiqiang Ruan
(Shenzhen Key Lab of Marine Genomics, State Key Laboratory of Agricultural Genomics
BGI-Shenzhen)
- Jie Bai
(Shenzhen Key Lab of Marine Genomics, State Key Laboratory of Agricultural Genomics
BGI-Shenzhen)
- Chao Peng
(Shenzhen Key Lab of Marine Genomics, State Key Laboratory of Agricultural Genomics
BGI-Shenzhen)
- Qian Mu
(BGI-Shenzhen)
- Jun Lu
(BGI-Shenzhen
Shenzhen BGI Fisheries Sci & Tech Co. Ltd)
- Mingjun Fan
(Center for Fish Genomics, BGI-Wuhan)
- Shuang Yang
(BGI-Shenzhen
Center for Fish Genomics, BGI-Wuhan)
- Zhiyong Huang
(BGI-Shenzhen)
- Xuanting Jiang
(BGI-Shenzhen)
- Xiaodong Fang
(BGI-Shenzhen)
- Guojie Zhang
(BGI-Shenzhen)
- Yong Zhang
(BGI-Shenzhen)
- Gianluca Polgar
(Environmental and Life Sciences Programme, Faculty of Science, Universiti Brunei Darussalam, Jln Tungku Link)
- Hui Yu
(Shenzhen Key Lab of Marine Genomics, State Key Laboratory of Agricultural Genomics
BGI-Shenzhen)
- Jia Li
(Shenzhen Key Lab of Marine Genomics, State Key Laboratory of Agricultural Genomics
BGI-Shenzhen)
- Zhongjian Liu
(Shenzhen Key Laboratory for Orchid Conservation and Utilization of the Orchid Conservation and Research Center of Shenzhen)
- Guoqiang Zhang
(Shenzhen Key Laboratory for Orchid Conservation and Utilization of the Orchid Conservation and Research Center of Shenzhen)
- Vydianathan Ravi
(Institute of Molecular and Cell Biology, A*STAR, Biopolis)
- Steven L. Coon
(Molecular Genomics Laboratory, National Institutes of Health)
- Jian Wang
(BGI-Shenzhen
James D. Watson Institute of Genome Science)
- Huanming Yang
(BGI-Shenzhen
James D. Watson Institute of Genome Science
Princess Al Jawhara Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University)
- Byrappa Venkatesh
(Institute of Molecular and Cell Biology, A*STAR, Biopolis)
- Jun Wang
(BGI-Shenzhen
Princess Al Jawhara Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University
University of Copenhagen)
- Qiong Shi
(Shenzhen Key Lab of Marine Genomics, State Key Laboratory of Agricultural Genomics
BGI-Shenzhen
Shenzhen BGI Fisheries Sci & Tech Co. Ltd
Center for Fish Genomics, BGI-Wuhan)
Abstract
Mudskippers are amphibious fishes that have developed morphological and physiological adaptations to match their unique lifestyles. Here we perform whole-genome sequencing of four representative mudskippers to elucidate the molecular mechanisms underlying these adaptations. We discover an expansion of innate immune system genes in the mudskippers that may provide defence against terrestrial pathogens. Several genes of the ammonia excretion pathway in the gills have experienced positive selection, suggesting their important roles in mudskippers’ tolerance to environmental ammonia. Some vision-related genes are differentially lost or mutated, illustrating genomic changes associated with aerial vision. Transcriptomic analyses of mudskippers exposed to air highlight regulatory pathways that are up- or down-regulated in response to hypoxia. The present study provides a valuable resource for understanding the molecular mechanisms underlying water-to-land transition of vertebrates.
Suggested Citation
Xinxin You & Chao Bian & Qijie Zan & Xun Xu & Xin Liu & Jieming Chen & Jintu Wang & Ying Qiu & Wujiao Li & Xinhui Zhang & Ying Sun & Shixi Chen & Wanshu Hong & Yuxiang Li & Shifeng Cheng & Guangyi Fan, 2014.
"Mudskipper genomes provide insights into the terrestrial adaptation of amphibious fishes,"
Nature Communications, Nature, vol. 5(1), pages 1-8, December.
Handle:
RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6594
DOI: 10.1038/ncomms6594
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