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Regulation of Drosophila circadian rhythms by miRNA let-7 is mediated by a regulatory cycle

Author

Listed:
  • Wenfeng Chen

    (College of Agronomy and Biotechnology, China Agricultural University)

  • Zhenxing Liu

    (College of Agronomy and Biotechnology, China Agricultural University)

  • Tianjiao Li

    (College of Agronomy and Biotechnology, China Agricultural University)

  • Ruifeng Zhang

    (College of Agronomy and Biotechnology, China Agricultural University)

  • Yongbo Xue

    (College of Agronomy and Biotechnology, China Agricultural University)

  • Yang Zhong

    (College of Agronomy and Biotechnology, China Agricultural University)

  • Weiwei Bai

    (College of Agronomy and Biotechnology, China Agricultural University)

  • Dasen Zhou

    (College of Agronomy and Biotechnology, China Agricultural University)

  • Zhangwu Zhao

    (College of Agronomy and Biotechnology, China Agricultural University)

Abstract

MicroRNA-mediated post-transcriptional regulations are increasingly recognized as important components of the circadian rhythm. Here we identify microRNA let-7, part of the Drosophila let-7-Complex, as a regulator of circadian rhythms mediated by a circadian regulatory cycle. Overexpression of let-7 in clock neurons lengthens circadian period and its deletion attenuates the morning activity peak as well as molecular oscillation. Let-7 regulates the circadian rhythm via repression of CLOCKWORK ORANGE (CWO). Conversely, upregulated cwo in cwo-expressing cells can rescue the phenotype of let-7-Complex overexpression. Moreover, circadian prothoracicotropic hormone (PTTH) and CLOCK-regulated 20-OH ecdysteroid signalling contribute to the circadian expression of let-7 through the 20-OH ecdysteroid receptor. Thus, we find a regulatory cycle involving PTTH, a direct target of CLOCK, and PTTH-driven miRNA let-7.

Suggested Citation

  • Wenfeng Chen & Zhenxing Liu & Tianjiao Li & Ruifeng Zhang & Yongbo Xue & Yang Zhong & Weiwei Bai & Dasen Zhou & Zhangwu Zhao, 2014. "Regulation of Drosophila circadian rhythms by miRNA let-7 is mediated by a regulatory cycle," Nature Communications, Nature, vol. 5(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6549
    DOI: 10.1038/ncomms6549
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