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Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice

Author

Listed:
  • Simon Gritsch

    (Institute for Pharmacology, University of Heidelberg)

  • Jianning Lu

    (Institute for Pharmacology, University of Heidelberg)

  • Sebastian Thilemann

    (Institute for Pharmacology, University of Heidelberg)

  • Simone Wörtge

    (Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz)

  • Wiebke Möbius

    (Max Planck Institute of Experimental Medicine
    Center Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB))

  • Julia Bruttger

    (Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz)

  • Khalad Karram

    (Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz)

  • Torben Ruhwedel

    (Max Planck Institute of Experimental Medicine)

  • Michaela Blanfeld

    (Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz)

  • Daniel Vardeh

    (Institute for Pharmacology, University of Heidelberg)

  • Ari Waisman

    (Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz)

  • Klaus-Armin Nave

    (Max Planck Institute of Experimental Medicine)

  • Rohini Kuner

    (Institute for Pharmacology, University of Heidelberg)

Abstract

Mechanisms underlying central neuropathic pain are poorly understood. Although glial dysfunction has been functionally linked with neuropathic pain, very little is known about modulation of pain by oligodendrocytes. Here we report that genetic ablation of oligodendrocytes rapidly triggers a pattern of sensory changes that closely resemble central neuropathic pain, which are manifest before overt demyelination. Primary oligodendrocyte loss is not associated with autoreactive T- and B-cell infiltration in the spinal cord and neither activation of microglia nor reactive astrogliosis contribute functionally to central pain evoked by ablation of oligodendrocytes. Instead, light and electron microscopic analyses reveal axonal pathology in the spinal dorsal horn and spinothalamic tract concurrent with the induction and maintenance of nociceptive hypersensitivity. These data reveal a role for oligodendrocytes in modulating pain and suggest that perturbation of oligodendrocyte functions that maintain axonal integrity can lead to central neuropathic pain independent of immune contributions.

Suggested Citation

  • Simon Gritsch & Jianning Lu & Sebastian Thilemann & Simone Wörtge & Wiebke Möbius & Julia Bruttger & Khalad Karram & Torben Ruhwedel & Michaela Blanfeld & Daniel Vardeh & Ari Waisman & Klaus-Armin Nav, 2014. "Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice," Nature Communications, Nature, vol. 5(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6472
    DOI: 10.1038/ncomms6472
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