IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v5y2014i1d10.1038_ncomms6457.html
   My bibliography  Save this article

Genomic landscape of metastatic colorectal cancer

Author

Listed:
  • Josien C. Haan

    (VU University Medical Center)

  • Mariette Labots

    (VU University Medical Center)

  • Christian Rausch

    (VU University Medical Center)

  • Miriam Koopman

    (University Medical Center Utrecht)

  • Jolien Tol

    (Radboud University Medical Centre)

  • Leonie J. M. Mekenkamp

    (Radboud University Medical Centre)

  • Mark A. van de Wiel

    (VU University Medical Center)

  • Danielle Israeli

    (VU University Medical Center)

  • Hendrik F. van Essen

    (VU University Medical Center)

  • Nicole C. T. van Grieken

    (VU University Medical Center)

  • Quirinus J. M. Voorham

    (VU University Medical Center)

  • Linda J. W. Bosch

    (VU University Medical Center)

  • Xueping Qu

    (Oncology Biomarker Development, Genentech, Inc.)

  • Omar Kabbarah

    (Oncology Biomarker Development, Genentech, Inc.)

  • Henk M. W. Verheul

    (VU University Medical Center)

  • Iris D. Nagtegaal

    (Radboud University Medical Centre)

  • Cornelis J. A. Punt

    (Academic Medical Center)

  • Bauke Ylstra

    (VU University Medical Center)

  • Gerrit A. Meijer

    (VU University Medical Center)

Abstract

Response to drug therapy in individual colorectal cancer (CRC) patients is associated with tumour biology. Here we describe the genomic landscape of tumour samples of a homogeneous well-annotated series of patients with metastatic CRC (mCRC) of two phase III clinical trials, CAIRO and CAIRO2. DNA copy number aberrations of 349 patients are determined. Within three treatment arms, 194 chromosomal subregions are associated with progression-free survival (PFS; uncorrected single-test P-values

Suggested Citation

  • Josien C. Haan & Mariette Labots & Christian Rausch & Miriam Koopman & Jolien Tol & Leonie J. M. Mekenkamp & Mark A. van de Wiel & Danielle Israeli & Hendrik F. van Essen & Nicole C. T. van Grieken & , 2014. "Genomic landscape of metastatic colorectal cancer," Nature Communications, Nature, vol. 5(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6457
    DOI: 10.1038/ncomms6457
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms6457
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms6457?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6457. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.