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The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis

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  • Miju Kim

    (National Creative Research Initiatives Center, Korea Advanced Institute of Science and Technology (KAIST))

  • Minchul Kim

    (National Creative Research Initiatives Center, Korea Advanced Institute of Science and Technology (KAIST))

  • Mi-Sun Lee

    (Chungnam National University)

  • Cheol-Hee Kim

    (Chungnam National University)

  • Dae-Sik Lim

    (National Creative Research Initiatives Center, Korea Advanced Institute of Science and Technology (KAIST))

Abstract

Primary cilia are microtubule-based organelles that protrude from polarized epithelial cells. Although many structural and trafficking molecules that regulate ciliogenesis have been discovered, signalling proteins are not well defined. Here we show that the MST1/2-SAV1 complex, a core component of the Hippo pathway, promotes ciliogenesis. MST1 is activated during ciliogenesis and localizes to the basal body of cilia. Depletion of MST1/2 or SAV1 impairs ciliogenesis in cultured cells and induces ciliopathy phenotypes in zebrafish. MST1/2-SAV1 regulates ciliogenesis through two independent mechanisms: MST1/2 binds and phosphorylates Aurora kinase A (AURKA), leading to dissociation of the AURKA/HDAC6 cilia-disassembly complex; and MST1/2-SAV1 associates with the NPHP transition-zone complex, promoting ciliary localization of multiple ciliary cargoes. Our results suggest that components of the Hippo pathway contribute to establish a polarized cell structure in addition to regulating proliferation.

Suggested Citation

  • Miju Kim & Minchul Kim & Mi-Sun Lee & Cheol-Hee Kim & Dae-Sik Lim, 2014. "The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis," Nature Communications, Nature, vol. 5(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6370
    DOI: 10.1038/ncomms6370
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