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Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines

Author

Listed:
  • Romain Banchereau

    (Baylor Institute for Immunology Research)

  • Nicole Baldwin

    (Baylor Institute for Immunology Research)

  • Alma-Martina Cepika

    (Baylor Institute for Immunology Research)

  • Shruti Athale

    (Baylor Institute for Immunology Research)

  • Yaming Xue

    (Baylor Institute for Immunology Research)

  • Chun I Yu

    (Baylor Institute for Immunology Research)

  • Patrick Metang

    (Baylor Institute for Immunology Research)

  • Abhilasha Cheruku

    (Baylor Institute for Immunology Research)

  • Isabelle Berthier

    (Baylor Institute for Immunology Research)

  • Ingrid Gayet

    (Baylor Institute for Immunology Research)

  • Yuanyuan Wang

    (Baylor Institute for Immunology Research)

  • Marina Ohouo

    (Baylor Institute for Immunology Research)

  • LuAnn Snipes

    (Baylor Institute for Immunology Research)

  • Hui Xu

    (Baylor Institute for Immunology Research)

  • Gerlinde Obermoser

    (Baylor Institute for Immunology Research)

  • Derek Blankenship

    (Baylor Institute for Immunology Research)

  • Sangkon Oh

    (Baylor Institute for Immunology Research)

  • Octavio Ramilo

    (Nationwide Children’s Hospital)

  • Damien Chaussabel

    (Benaroya Research Institute
    Sidra Medical and Research Center)

  • Jacques Banchereau

    (Baylor Institute for Immunology Research
    Jackson Laboratory for Genomic Medicine)

  • Karolina Palucka

    (Baylor Institute for Immunology Research
    Jackson Laboratory for Genomic Medicine)

  • Virginia Pascual

    (Baylor Institute for Immunology Research)

Abstract

The mechanisms by which microbial vaccines interact with human APCs remain elusive. Herein, we describe the transcriptional programs induced in human DCs by pathogens, innate receptor ligands and vaccines. Exposure of DCs to influenza, Salmonella enterica and Staphylococcus aureus allows us to build a modular framework containing 204 transcript clusters. We use this framework to characterize the responses of human monocytes, monocyte-derived DCs and blood DC subsets to 13 vaccines. Different vaccines induce distinct transcriptional programs based on pathogen type, adjuvant formulation and APC targeted. Fluzone, Pneumovax and Gardasil, respectively, activate monocyte-derived DCs, monocytes and CD1c+ blood DCs, highlighting APC specialization in response to vaccines. Finally, the blood signatures from individuals vaccinated with Fluzone or infected with influenza reveal a signature of adaptive immunity activation following vaccination and symptomatic infections, but not asymptomatic infections. These data, offered with a web interface, may guide the development of improved vaccines.

Suggested Citation

  • Romain Banchereau & Nicole Baldwin & Alma-Martina Cepika & Shruti Athale & Yaming Xue & Chun I Yu & Patrick Metang & Abhilasha Cheruku & Isabelle Berthier & Ingrid Gayet & Yuanyuan Wang & Marina Ohouo, 2014. "Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines," Nature Communications, Nature, vol. 5(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6283
    DOI: 10.1038/ncomms6283
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