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Enzymatic aerobic ring rearrangement of optically active furylcarbinols

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  • Daniel Thiel

    (Universität zu Köln)

  • Diana Doknić

    (Universität zu Köln)

  • Jan Deska

    (Universität zu Köln)

Abstract

Biogenic furans are currently discussed as highly attractive alternative feedstock in a post-fossil society; thus, also the creation of sustainable furan valorization pathways appears of great importance. Here an artificial Achmatowicz monooxygenase activity for the aerobic ring expansion of furans is achieved by the combination of commercial glucose oxidase as oxygen-activating biocatalyst and wild-type chloroperoxidase as oxygen-transfer mediator, providing a biological ready-to-use solution for this truly synthetic furan rearrangement. In concert with enzymatic transformations for the enantioselective preparation of optically active furylcarbinols, purely biocatalytic reaction cascades for the stereocontrolled construction of complex pyranones are obtained, exhibiting high functional group tolerance even to oxidation-sensitive moieties.

Suggested Citation

  • Daniel Thiel & Diana Doknić & Jan Deska, 2014. "Enzymatic aerobic ring rearrangement of optically active furylcarbinols," Nature Communications, Nature, vol. 5(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6278
    DOI: 10.1038/ncomms6278
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