IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v5y2014i1d10.1038_ncomms6150.html
   My bibliography  Save this article

NK1.1+ CD8+ T cells escape TGF-β control and contribute to early microbial pathogen response

Author

Listed:
  • Anne L. Ruiz

    (Cancer Research Center of Lyon UMR INSERM 1052 CNRS 5286, Immunology, 28 rue Laennec
    LabEx DEVweCAN
    Université Lyon 1
    Centre Léon Bérard, Lyon)

  • Saidi M’Homa Soudja

    (Albert Einstein College of Medicine of Yeshiva University)

  • Cyril Deceneux

    (Cancer Research Center of Lyon UMR INSERM 1052 CNRS 5286, Immunology, 28 rue Laennec
    LabEx DEVweCAN
    Université Lyon 1
    Centre Léon Bérard, Lyon)

  • Grégoire Lauvau

    (Albert Einstein College of Medicine of Yeshiva University)

  • Julien C. Marie

    (Cancer Research Center of Lyon UMR INSERM 1052 CNRS 5286, Immunology, 28 rue Laennec
    LabEx DEVweCAN
    Université Lyon 1
    Centre Léon Bérard, Lyon)

Abstract

Following microbial pathogen invasion, one of the main challenges for the host is to rapidly control pathogen spreading to avoid vital tissue damage. Here we report that an effector CD8+ T-cell population that expresses the marker NK1.1 undergoes delayed contraction and sustains early anti-microbial protection. NK1.1+ CD8+ T cells are derived from CD8+ T cells during priming, and their differentiation is inhibited by transforming growth factor-β signalling. After their own contraction phase, they form a distinct pool of KLRG1 CD127 double-positive memory T cells and rapidly produce both interferon-γ and granzyme B, providing significant pathogen protection in an antigen-independent manner within only a few hours. Thus, by prolonging the CD8+ T-cell response at the effector stage and by expressing exacerbated innate-like features at the memory stage, NK1.1+ cells represent a distinct subset of CD8+ T cell that contributes to the early control of microbial pathogen re-infections.

Suggested Citation

  • Anne L. Ruiz & Saidi M’Homa Soudja & Cyril Deceneux & Grégoire Lauvau & Julien C. Marie, 2014. "NK1.1+ CD8+ T cells escape TGF-β control and contribute to early microbial pathogen response," Nature Communications, Nature, vol. 5(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6150
    DOI: 10.1038/ncomms6150
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms6150
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms6150?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6150. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.