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Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity

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Listed:
  • Erwan Pernet

    (Unité de défense innée et inflammation, Institut Pasteur
    INSERM U874
    Université Pierre et Marie Curie, Cellule Pasteur UPMC, rue du Dr Roux)

  • Laurent Guillemot

    (Unité de défense innée et inflammation, Institut Pasteur
    INSERM U874)

  • Pierre-Régis Burgel

    (Université Paris Descartes, Sorbonne Paris Cité
    Service de Pneumologie, Hôpital Cochin, AP-HP)

  • Clémence Martin

    (Université Paris Descartes, Sorbonne Paris Cité
    Service de Pneumologie, Hôpital Cochin, AP-HP)

  • Gérard Lambeau

    (Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275 Centre National de la Recherche Scientifique et Université de Nice Sophia Antipolis)

  • Isabelle Sermet-Gaudelus

    (INSERM U 806, Université René Descartes, CRCM, Service de Pneumo-Pédiatrie, Hôpital Necker-Enfants Malades)

  • Dorota Sands

    (Institute of Mother and Child, CF Centre)

  • Dominique Leduc

    (Unité de défense innée et inflammation, Institut Pasteur
    INSERM U874)

  • Philippe C. Morand

    (Université Paris Descartes, Sorbonne Paris Cité
    Service de Bactériologie, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris)

  • Louise Jeammet

    (Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275 Centre National de la Recherche Scientifique et Université de Nice Sophia Antipolis)

  • Michel Chignard

    (Unité de défense innée et inflammation, Institut Pasteur
    INSERM U874)

  • Yongzheng Wu

    (Unité de défense innée et inflammation, Institut Pasteur
    INSERM U874)

  • Lhousseine Touqui

    (Unité de défense innée et inflammation, Institut Pasteur
    INSERM U874)

Abstract

Young cystic fibrosis (CF) patients’ airways are mainly colonized by Staphylococcus aureus, while Pseudomonas aeruginosa predominates in adults. However, the mechanisms behind this infection switch are unclear. Here, we show that levels of type-IIA-secreted phospholipase A2 (sPLA2-IIA, a host enzyme with bactericidal activity) increase in expectorations of CF patients in an age-dependent manner. These levels are sufficient to kill S. aureus, with marginal effects on P. aeruginosa strains. P. aeruginosa laboratory strains and isolates from CF patients induce sPLA2-IIA expression in bronchial epithelial cells from CF patients (these cells are a major source of the enzyme). In an animal model of lung infection, P. aeruginosa induces sPLA2-IIA production that favours S. aureus killing. We suggest that sPLA2-IIA induction by P. aeruginosa contributes to S. aureus eradication in CF airways. Our results indicate that a bacterium can eradicate another bacterium by manipulating the host immunity.

Suggested Citation

  • Erwan Pernet & Laurent Guillemot & Pierre-Régis Burgel & Clémence Martin & Gérard Lambeau & Isabelle Sermet-Gaudelus & Dorota Sands & Dominique Leduc & Philippe C. Morand & Louise Jeammet & Michel Chi, 2014. "Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity," Nature Communications, Nature, vol. 5(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6105
    DOI: 10.1038/ncomms6105
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