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Magneto-fluorescent core-shell supernanoparticles

Author

Listed:
  • Ou Chen

    (Massachusetts Institute of Technology)

  • Lars Riedemann

    (Massachusetts General Hospital and Harvard Medical School)

  • Fred Etoc

    (Laboratoire Physico-Chimie Curie, Institut Curie)

  • Hendrik Herrmann

    (Heinrich-Pette-Institute
    Bernhard-Nocht-Institute for Tropical Medicine)

  • Mathieu Coppey

    (Laboratoire Physico-Chimie Curie, Institut Curie)

  • Mariya Barch

    (Massachusetts Institute of Technology)

  • Christian T. Farrar

    (Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital)

  • Jing Zhao

    (Massachusetts Institute of Technology)

  • Oliver T. Bruns

    (Massachusetts Institute of Technology)

  • He Wei

    (Massachusetts Institute of Technology)

  • Peng Guo

    (Vascular Biology Program, Children’s Hospital Boston, Harvard Medical School)

  • Jian Cui

    (Massachusetts Institute of Technology)

  • Russ Jensen

    (Massachusetts Institute of Technology)

  • Yue Chen

    (Massachusetts Institute of Technology)

  • Daniel K. Harris

    (Massachusetts Institute of Technology)

  • Jose M. Cordero

    (Massachusetts Institute of Technology)

  • Zhongwu Wang

    (Cornell High Energy Synchrotron Source (CHESS), Wilson Laboratory, Cornell University)

  • Alan Jasanoff

    (Massachusetts Institute of Technology
    Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

  • Dai Fukumura

    (Massachusetts General Hospital and Harvard Medical School)

  • Rudolph Reimer

    (Heinrich-Pette-Institute)

  • Maxime Dahan

    (Laboratoire Physico-Chimie Curie, Institut Curie)

  • Rakesh K. Jain

    (Massachusetts General Hospital and Harvard Medical School)

  • Moungi G. Bawendi

    (Massachusetts Institute of Technology)

Abstract

Magneto-fluorescent particles have been recognized as an emerging class of materials that exhibit great potential in advanced applications. However, synthesizing such magneto-fluorescent nanomaterials that simultaneously exhibit uniform and tunable sizes, high magnetic content loading, maximized fluorophore coverage at the surface and a versatile surface functionality has proven challenging. Here we report a simple approach for co-assembling magnetic nanoparticles with fluorescent quantum dots to form colloidal magneto-fluorescent supernanoparticles. Importantly, these supernanoparticles exhibit a superstructure consisting of a close-packed magnetic nanoparticle ‘core’, which is fully surrounded by a ‘shell’ of fluorescent quantum dots. A thin layer of silica coating provides high colloidal stability and biocompatibility, and a versatile surface functionality. We demonstrate that after surface pegylation, these silica-coated magneto-fluorescent supernanoparticles can be magnetically manipulated inside living cells while being optically tracked. Moreover, our silica-coated magneto-fluorescent supernanoparticles can also serve as an in vivo multi-photon and magnetic resonance dual-modal imaging probe.

Suggested Citation

  • Ou Chen & Lars Riedemann & Fred Etoc & Hendrik Herrmann & Mathieu Coppey & Mariya Barch & Christian T. Farrar & Jing Zhao & Oliver T. Bruns & He Wei & Peng Guo & Jian Cui & Russ Jensen & Yue Chen & Da, 2014. "Magneto-fluorescent core-shell supernanoparticles," Nature Communications, Nature, vol. 5(1), pages 1-8, December.
  • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6093
    DOI: 10.1038/ncomms6093
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