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Functional ultrasound imaging of intrinsic connectivity in the living rat brain with high spatiotemporal resolution

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  • Bruno-Félix Osmanski

    (Institut Langevin, ESPCI-ParisTech
    CNRS UMR 7587
    INSERM U979 ‘Wave Physics for Medicine’ Lab)

  • Sophie Pezet

    (Centre National pour la Recherche Scientifique, UMR 8249
    Brain Plasticity Unit, ESPCI-ParisTech)

  • Ana Ricobaraza

    (Centre National pour la Recherche Scientifique, UMR 8249
    Brain Plasticity Unit, ESPCI-ParisTech)

  • Zsolt Lenkei

    (Centre National pour la Recherche Scientifique, UMR 8249
    Brain Plasticity Unit, ESPCI-ParisTech)

  • Mickael Tanter

    (Institut Langevin, ESPCI-ParisTech
    CNRS UMR 7587
    INSERM U979 ‘Wave Physics for Medicine’ Lab)

Abstract

Long-range coherences in spontaneous brain activity reflect functional connectivity. Here we propose a novel, highly resolved connectivity mapping approach, using ultrafast functional ultrasound (fUS), which enables imaging of cerebral microvascular haemodynamics deep in the anaesthetized rodent brain, through a large thinned-skull cranial window, with pixel dimensions of 100 μm × 100 μm in-plane. The millisecond-range temporal resolution allows unambiguous cancellation of low-frequency cardio-respiratory noise. Both seed-based and singular value decomposition analysis of spatial coherences in the low-frequency (

Suggested Citation

  • Bruno-Félix Osmanski & Sophie Pezet & Ana Ricobaraza & Zsolt Lenkei & Mickael Tanter, 2014. "Functional ultrasound imaging of intrinsic connectivity in the living rat brain with high spatiotemporal resolution," Nature Communications, Nature, vol. 5(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6023
    DOI: 10.1038/ncomms6023
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