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Metabolic properties in stroked rats revealed by relaxation-enhanced magnetic resonance spectroscopy at ultrahigh fields

Author

Listed:
  • Noam Shemesh

    (Weizmann Institute of Science)

  • Jens T. Rosenberg

    (National High Magnetic Field Laboratory, The Florida State University
    Chemical and Biomedical Engineering, The Florida State University)

  • Jean-Nicolas Dumez

    (Weizmann Institute of Science)

  • Jose A. Muniz

    (National High Magnetic Field Laboratory, The Florida State University
    Chemical and Biomedical Engineering, The Florida State University)

  • Samuel C. Grant

    (National High Magnetic Field Laboratory, The Florida State University
    Chemical and Biomedical Engineering, The Florida State University)

  • Lucio Frydman

    (Weizmann Institute of Science
    National High Magnetic Field Laboratory, The Florida State University)

Abstract

1H magnetic resonance spectroscopy (MRS) yields site-specific signatures that directly report metabolic concentrations, biochemistry and kinetics—provided spectral sensitivity and quality are sufficient. Here, an enabling relaxation-enhanced (RE) MRS approach is demonstrated that by combining highly selective spectral excitations with operation at very high magnetic fields, delivers spectra exhibiting signal-to-noise ratios >50:1 in under 6 s for ~5 × 5 × 5 (mm)3 voxels, with flat baselines and no interference from water. With this spectral quality, MRS was used to interrogate a number of metabolic properties in stroked rat models. Metabolic confinements imposed by randomly oriented micro-architectures were detected and found to change upon ischaemia; intensities of downfield resonances were found to be selectively altered in stroked hemispheres; and longitudinal relaxation time of lactic acid was found to increase by over 50% its control value as early as 3-h post ischaemia, paralleling the onset of cytotoxic oedema. These results demonstrate potential of 1H MRS at ultrahigh fields.

Suggested Citation

  • Noam Shemesh & Jens T. Rosenberg & Jean-Nicolas Dumez & Jose A. Muniz & Samuel C. Grant & Lucio Frydman, 2014. "Metabolic properties in stroked rats revealed by relaxation-enhanced magnetic resonance spectroscopy at ultrahigh fields," Nature Communications, Nature, vol. 5(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5958
    DOI: 10.1038/ncomms5958
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