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The transcription factor Apontic-like controls diverse colouration pattern in caterpillars

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  • Shinichi Yoda

    (University of Tokyo)

  • Junichi Yamaguchi

    (University of Tokyo)

  • Kazuei Mita

    (Invertebrate Gene Function Research Unit, National Institute of Agrobiological Sciences)

  • Kimiko Yamamoto

    (Invertebrate Gene Function Research Unit, National Institute of Agrobiological Sciences)

  • Yutaka Banno

    (Laboratory of Insect Genetic Resources, Faculty of Agriculture, Kyushu University)

  • Toshiya Ando

    (University of Tokyo)

  • Takaaki Daimon

    (National Institute of Agrobiological Sciences)

  • Haruhiko Fujiwara

    (University of Tokyo)

Abstract

Genetic polymorphisms underlie the convergent and divergent evolution of various phenotypes. Diverse colour patterns on caterpillars, which are ecologically important, are good models for understanding the molecular backgrounds of phenotypic diversity. Here we show that a single evolutionarily conserved gene apontic-like (apt-like) encoding for a putative transcription factor accounts for the silkworm p locus, which causes at least 15 different larval markings involved in branch-like markings and eye-spot formation. The expression of apt-like and melanin synthesis genes are upregulated in association with pigmented areas of marking mutants Striped (pS) and normal (+p) but not in the non-marking allele plain (p). Functional analyses, ectopic expression, RNAi and TALEN, demonstrate that apt-like causes melanin pigmentation in a cell-autonomous manner. These results suggest that variation in p alleles is caused by the differential expression of the gene apt-like which induces targeted elevation of gene expressions in the melanin synthesis pathway.

Suggested Citation

  • Shinichi Yoda & Junichi Yamaguchi & Kazuei Mita & Kimiko Yamamoto & Yutaka Banno & Toshiya Ando & Takaaki Daimon & Haruhiko Fujiwara, 2014. "The transcription factor Apontic-like controls diverse colouration pattern in caterpillars," Nature Communications, Nature, vol. 5(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5936
    DOI: 10.1038/ncomms5936
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