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Magnetic antibody-linked nanomatchmakers for therapeutic cell targeting

Author

Listed:
  • Ke Cheng

    (Cedars-Sinai Heart Institute
    Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, 1060 William Moore Drive, North Carolina State University
    University of North Carolina at Chapel Hill and North Carolina State University)

  • Deliang Shen

    (First Affiliated Hospital of Zhengzhou University)

  • M. Taylor Hensley

    (Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, 1060 William Moore Drive, North Carolina State University)

  • Ryan Middleton

    (Cedars-Sinai Heart Institute)

  • Baiming Sun

    (Cedars-Sinai Heart Institute)

  • Weixin Liu

    (Cedars-Sinai Heart Institute)

  • Geoffrey De Couto

    (Cedars-Sinai Heart Institute)

  • Eduardo Marbán

    (Cedars-Sinai Heart Institute)

Abstract

Stem cell transplantation is a promising strategy for therapeutic cardiac regeneration, but current therapies are limited by inefficient interaction between potentially beneficial cells (either exogenously transplanted or endogenously recruited) and the injured tissue. Here we apply targeted nanomedicine to achieve in vivo cell-mediated tissue repair, imaging and localized enrichment without cellular transplantation. Iron nanoparticles are conjugated with two types of antibodies (one against antigens on therapeutic cells and the other directed at injured cells) to produce magnetic bifunctional cell engager (MagBICE). The antibodies link the therapeutic cells to the injured cells, whereas the iron core of MagBICE enables physical enrichment and imaging. We treat acute myocardial infarction by targeting exogenous bone marrow-derived stem cells (expressing CD45) or endogenous CD34-positive cells to injured cardiomyocytes (expressing myosin light chain. Targeting can be further enhanced by magnetic attraction, leading to augmented functional benefits. MagBICE represents a generalizable platform technology for regenerative medicine.

Suggested Citation

  • Ke Cheng & Deliang Shen & M. Taylor Hensley & Ryan Middleton & Baiming Sun & Weixin Liu & Geoffrey De Couto & Eduardo Marbán, 2014. "Magnetic antibody-linked nanomatchmakers for therapeutic cell targeting," Nature Communications, Nature, vol. 5(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5880
    DOI: 10.1038/ncomms5880
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