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UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation

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  • Cristina Militti

    (Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG)
    Universitat Pompeu Fabra (UPF))

  • Sylvain Maenner

    (Adolf-Butenandt-Institute and Center for Integrated Protein Science, Ludwig-Maximilians University)

  • Peter B. Becker

    (Adolf-Butenandt-Institute and Center for Integrated Protein Science, Ludwig-Maximilians University)

  • Fátima Gebauer

    (Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG)
    Universitat Pompeu Fabra (UPF))

Abstract

Dosage compensation is a regulatory process that balances the expression of X-chromosomal genes between males (XY) and females (XX). In Drosophila, this requires non-coding RNAs and RNA-binding proteins (RBPs) whose specific functions remain elusive. Here we show that the Drosophila RBP UNR promotes the targeting of the activating male-specific-lethal complex to the X-chromosome by facilitating the interaction of two crucial subunits: the RNA helicase MLE and the long non-coding RNA roX2.

Suggested Citation

  • Cristina Militti & Sylvain Maenner & Peter B. Becker & Fátima Gebauer, 2014. "UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation," Nature Communications, Nature, vol. 5(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5762
    DOI: 10.1038/ncomms5762
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