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Identification of TERRA locus unveils a telomere protection role through association to nearly all chromosomes

Author

Listed:
  • Isabel López de Silanes

    (Telomeres and Telomerase Group, Spanish National Cancer Research Centre (CNIO))

  • Osvaldo Graña

    (Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO))

  • Maria Luigia De Bonis

    (Telomeres and Telomerase Group, Spanish National Cancer Research Centre (CNIO))

  • Orlando Dominguez

    (Genomics Unit, Spanish National Cancer Research Centre (CNIO))

  • David G Pisano

    (Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO))

  • Maria A Blasco

    (Telomeres and Telomerase Group, Spanish National Cancer Research Centre (CNIO))

Abstract

Telomeric RNAs (TERRAs) are UUAGGG repeat-containing RNAs that are transcribed from the subtelomere towards the telomere. The precise genomic origin of TERRA has remained elusive. Using a whole-genome RNA-sequencing approach, we identify novel mouse transcripts arising mainly from the subtelomere of chromosome 18, and to a lesser extend chromosome 9, that resemble TERRA in several key aspects. Those transcripts contain UUAGGG-repeats and are heterogeneous in size, fluctuate in abundance in a TERRA-like manner during the cell cycle, are bound by TERRA RNA-binding proteins and are regulated in a manner similar to TERRA in response to stress and the induction of pluripotency. These transcripts are also found to associate with nearly all chromosome ends and downregulation of the transcripts that originate from chromosome 18 causes a reduction in TERRA abundance. Interestingly, downregulation of either chromosome 18 transcripts or TERRA results in increased number of telomere dysfunction-induced foci, suggesting a protective role at telomeres.

Suggested Citation

  • Isabel López de Silanes & Osvaldo Graña & Maria Luigia De Bonis & Orlando Dominguez & David G Pisano & Maria A Blasco, 2014. "Identification of TERRA locus unveils a telomere protection role through association to nearly all chromosomes," Nature Communications, Nature, vol. 5(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5723
    DOI: 10.1038/ncomms5723
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