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Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A

Author

Listed:
  • Hansong Wang

    (Epidemiology Program, University of Hawaii Cancer Center)

  • Terrilea Burnett

    (Epidemiology Program, University of Hawaii Cancer Center)

  • Suminori Kono

    (Graduate School of Medical Sciences, Kyushu University)

  • Christopher A. Haiman

    (Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California)

  • Motoki Iwasaki

    (Research Center for Cancer Prevention and Screening, National Cancer Center)

  • Lynne R. Wilkens

    (Epidemiology Program, University of Hawaii Cancer Center)

  • Lenora W. M. Loo

    (Epidemiology Program, University of Hawaii Cancer Center)

  • David Van Den Berg

    (Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California)

  • Laurence N. Kolonel

    (Epidemiology Program, University of Hawaii Cancer Center)

  • Brian E. Henderson

    (Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California)

  • Temitope O. Keku

    (Center for Gastrointestinal Biology and Disease, University of North Carolina)

  • Robert S. Sandler

    (Center for Gastrointestinal Biology and Disease, University of North Carolina)

  • Lisa B. Signorello

    (Harvard School of Public Health, Harvard Medical School
    Dana-Farber/Harvard Cancer Center)

  • William J. Blot

    (Vanderbilt University Medical Center/Vanderbilt-Ingram Cancer Center
    International Epidemiology Institute)

  • Polly A. Newcomb

    (Cancer Prevention Program, Fred Hutchinson Cancer Research Center)

  • Mala Pande

    (the University of Texas MD Anderson Cancer Center)

  • Christopher I. Amos

    (Geisel School of Medicine, Dartmouth College)

  • Dee W. West

    (Cancer Prevention Institute of California)

  • Stéphane Bézieau

    (Service de Génétique Médicale, CHU Nantes)

  • Sonja I. Berndt

    (National Cancer Institute, National Institutes of Health)

  • Brent W. Zanke

    (Faculty of Medicine, University of Ottawa and Clinical Epidemiology Program, Ottawa Hospital Research Institute)

  • Li Hsu

    (Cancer Prevention Program, Fred Hutchinson Cancer Research Center)

  • Noralane M. Lindor
  • Robert W. Haile
  • John L. Hopper
  • Mark A. Jenkins
  • Steven Gallinger

    (Cancer Care Ontario)

  • Graham Casey

    (Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California)

  • Stephanie L. Stenzel

    (Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California)

  • Fredrick R. Schumacher
  • Ulrike Peters

    (Cancer Prevention Program, Fred Hutchinson Cancer Research Center)

  • Stephen B. Gruber
  • Shoichiro Tsugane

    (Research Center for Cancer Prevention and Screening, National Cancer Center)

  • Daniel O. Stram

    (Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California)

  • Loïc Le Marchand

Abstract

The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P

Suggested Citation

  • Hansong Wang & Terrilea Burnett & Suminori Kono & Christopher A. Haiman & Motoki Iwasaki & Lynne R. Wilkens & Lenora W. M. Loo & David Van Den Berg & Laurence N. Kolonel & Brian E. Henderson & Temitop, 2014. "Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A," Nature Communications, Nature, vol. 5(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5613
    DOI: 10.1038/ncomms5613
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