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Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity

Author

Listed:
  • Thomas Vogl

    (Institute of Immunology, University of Münster
    Interdisciplinary Centre for Clinical Research, University of Münster)

  • Michel Eisenblätter

    (King’s College London
    University of Münster)

  • Tom Völler

    (Institute of Immunology, University of Münster)

  • Stefanie Zenker

    (Institute of Immunology, University of Münster)

  • Sven Hermann

    (Interdisciplinary Centre for Clinical Research, University of Münster
    European Institute for Molecular Imaging, University of Münster)

  • Peter van Lent

    (Radboud University Medical Centre)

  • Andreas Faust

    (European Institute for Molecular Imaging, University of Münster)

  • Christiane Geyer

    (Interdisciplinary Centre for Clinical Research, University of Münster
    University of Münster)

  • Beatrix Petersen

    (Institute of Immunology, University of Münster)

  • Kirsten Roebrock

    (Institute of Immunology, University of Münster
    Interdisciplinary Centre for Clinical Research, University of Münster)

  • Michael Schäfers

    (European Institute for Molecular Imaging, University of Münster
    Cluster of Excellence EXC 1003 ‘Cells in Motion - CiM’, University of Münster)

  • Christoph Bremer

    (Interdisciplinary Centre for Clinical Research, University of Münster
    St Franziskus Hospital Münster)

  • Johannes Roth

    (Institute of Immunology, University of Münster
    Interdisciplinary Centre for Clinical Research, University of Münster
    Cluster of Excellence EXC 1003 ‘Cells in Motion - CiM’, University of Münster)

Abstract

Inflammation has a key role in the pathogenesis of various human diseases. The early detection, localization and monitoring of inflammation are crucial for tailoring individual therapies. However, reliable biomarkers to detect local inflammatory activities and to predict disease outcome are still missing. Alarmins, which are locally released during cellular stress, are early amplifiers of inflammation. Here, using optical molecular imaging, we demonstrate that the alarmin S100A8/S100A9 serves as a sensitive local and systemic marker for the detection of even sub-clinical disease activity in inflammatory and immunological processes like irritative and allergic contact dermatitis. In a model of collagen-induced arthritis, we use S100A8/S100A9 imaging to predict the development of disease activity. Furthermore, S100A8/S100A9 can act as a very early and sensitive biomarker in experimental leishmaniasis for phagocyte activation linked to an effective Th1-response. In conclusion, the alarmin S100A8/S100A9 is a valuable and sensitive molecular target for novel imaging approaches to monitor clinically relevant inflammatory disorders on a molecular level.

Suggested Citation

  • Thomas Vogl & Michel Eisenblätter & Tom Völler & Stefanie Zenker & Sven Hermann & Peter van Lent & Andreas Faust & Christiane Geyer & Beatrix Petersen & Kirsten Roebrock & Michael Schäfers & Christoph, 2014. "Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity," Nature Communications, Nature, vol. 5(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5593
    DOI: 10.1038/ncomms5593
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    Cited by:

    1. Debajyoti Ghosh & Lili Ding & Umasundari Sivaprasad & Esmond Geh & Jocelyn Biagini Myers & Jonathan A Bernstein & Gurjit K Khurana Hershey & Tesfaye B Mersha, 2015. "Multiple Transcriptome Data Analysis Reveals Biologically Relevant Atopic Dermatitis Signature Genes and Pathways," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-23, December.

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