IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v5y2014i1d10.1038_ncomms5513.html
   My bibliography  Save this article

NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation

Author

Listed:
  • Di-Feng Fang

    (State Key Laboratory of Proteomics, National Center of Biomedical Analysis, Institute of Basic Medical Sciences)

  • Kun He

    (State Key Laboratory of Proteomics, National Center of Biomedical Analysis, Institute of Basic Medical Sciences)

  • Na Wang

    (State Key Laboratory of Proteomics, National Center of Biomedical Analysis, Institute of Basic Medical Sciences)

  • Zhi-Hong Sang

    (State Key Laboratory of Proteomics, National Center of Biomedical Analysis, Institute of Basic Medical Sciences)

  • Xin Qiu

    (State Key Laboratory of Proteomics, National Center of Biomedical Analysis, Institute of Basic Medical Sciences)

  • Guang Xu

    (State Key Laboratory of Proteomics, National Center of Biomedical Analysis, Institute of Basic Medical Sciences)

  • Zhao Jian

    (State Key Laboratory of Proteomics, National Center of Biomedical Analysis, Institute of Basic Medical Sciences)

  • Bing Liang

    (State Key Laboratory of Proteomics, National Center of Biomedical Analysis, Institute of Basic Medical Sciences)

  • Tao Li

    (State Key Laboratory of Proteomics, National Center of Biomedical Analysis, Institute of Basic Medical Sciences)

  • Hui-Yan Li

    (State Key Laboratory of Proteomics, National Center of Biomedical Analysis, Institute of Basic Medical Sciences)

  • Ai-Ling Li

    (State Key Laboratory of Proteomics, National Center of Biomedical Analysis, Institute of Basic Medical Sciences)

  • Tao Zhou

    (State Key Laboratory of Proteomics, National Center of Biomedical Analysis, Institute of Basic Medical Sciences)

  • Wei-Li Gong

    (State Key Laboratory of Proteomics, National Center of Biomedical Analysis, Institute of Basic Medical Sciences)

  • Baoli Yang

    (Carver College of Medicine, University of Iowa, Iowa City)

  • Michael Karin

    (Laboratory of Gene Regulation and Signal Transduction, Cancer Center, University of California)

  • Xue-Min Zhang

    (State Key Laboratory of Proteomics, National Center of Biomedical Analysis, Institute of Basic Medical Sciences)

  • Wei-Hua Li

    (State Key Laboratory of Proteomics, National Center of Biomedical Analysis, Institute of Basic Medical Sciences)

Abstract

CD40, a member of tumour necrosis factor receptor (TNFR) superfamily, has a pivotal role in B-cell-mediated immunity through various effector pathways including AKT kinase, but the signal transduction of CD40-meidated AKT activation is poorly understood. Here we report that the neural precursor cell expressed developmentally downregulated protein 4 (NEDD4), homologous to E6-AP Carboxyl Terminus family E3 ubiquitin ligase, is a novel component of the CD40 signalling complex. It has a key role in CD40-mediated AKT activation and is involved in modulating immunoglobulin class switch through regulating the expression of activation-induced cytidine deaminase. NEDD4 constitutively interacts with CD40 and mediates K63-linked ubiquitination of TNFR-associated factor3 (TRAF3). The ubiquitination of TRAF3 by NEDD4 is critical for CD40-mediated AKT activation. Thus, NEDD4 is a previously unknown component of the CD40 signalling complex necessary for AKT activation.

Suggested Citation

  • Di-Feng Fang & Kun He & Na Wang & Zhi-Hong Sang & Xin Qiu & Guang Xu & Zhao Jian & Bing Liang & Tao Li & Hui-Yan Li & Ai-Ling Li & Tao Zhou & Wei-Li Gong & Baoli Yang & Michael Karin & Xue-Min Zhang &, 2014. "NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation," Nature Communications, Nature, vol. 5(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5513
    DOI: 10.1038/ncomms5513
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms5513
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms5513?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5513. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.