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LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria

Author

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  • Xiaomin Su

    (Nankai University School of Medicine, Nankai University)

  • Siping Min

    (Nankai University School of Medicine, Nankai University)

  • Shuisong Cao

    (Nankai University School of Medicine, Nankai University)

  • Hui Yan

    (Nankai University School of Medicine, Nankai University)

  • Yining Zhao

    (Nankai University School of Medicine, Nankai University)

  • Hui Li

    (Nankai University School of Medicine, Nankai University)

  • Limin Chai

    (Nankai University School of Medicine, Nankai University)

  • Shiyue Mei

    (Nankai University School of Medicine, Nankai University)

  • Jia Yang

    (Nankai University School of Medicine, Nankai University)

  • Yuan Zhang

    (Nankai University School of Medicine, Nankai University)

  • Zhujun Zhang

    (Nankai University School of Medicine, Nankai University)

  • Feifei Liu

    (Nankai University School of Medicine, Nankai University)

  • Wei Sun

    (Nankai University School of Medicine, Nankai University)

  • Yongzhe Che

    (Nankai University School of Medicine, Nankai University
    Key Laboratory of Bioactive Materials Ministry of Education, Nankai University)

  • Rongcun Yang

    (Nankai University School of Medicine, Nankai University
    Key Laboratory of Bioactive Materials Ministry of Education, Nankai University
    State Key Laboratory of Medicinal Chemical Biology, Nankai University)

Abstract

The innate immune-dependent bactericidal effects are critical for preventing microbial colonization in the urinary system. However, the mechanisms involved in establishing innate immune responses in kidney are not completely understood. Here we describe the role of a novel member of the LRR (leucine-rich repeat) class of transmembrane proteins, LRRC19 (LRR-containing 19) in eliminating uropathogenic bacteria. LRRC19 is predominantly expressed in human and mouse kidney tubular epithelial cells and LRRC19-deficient mice are more susceptible to uropathogenic Escherichia coli (UPEC) infection than wild-type or TLR4 knockout mice. Recognition of UPEC by LRRC19 induces the production of cytokines, chemokines and antimicrobial substances through TRAF2- and TRAF6-mediated NF-κB and MAPK signalling pathways. Thus, LRRC19 may be a critical pathogen-recognition receptor in kidney mediating the elimination of UPEC infection.

Suggested Citation

  • Xiaomin Su & Siping Min & Shuisong Cao & Hui Yan & Yining Zhao & Hui Li & Limin Chai & Shiyue Mei & Jia Yang & Yuan Zhang & Zhujun Zhang & Feifei Liu & Wei Sun & Yongzhe Che & Rongcun Yang, 2014. "LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria," Nature Communications, Nature, vol. 5(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5434
    DOI: 10.1038/ncomms5434
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