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Germline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour

Author

Listed:
  • Sandra Hanks

    (Institute of Cancer Research)

  • Elizabeth R. Perdeaux

    (Institute of Cancer Research)

  • Sheila Seal

    (Institute of Cancer Research)

  • Elise Ruark

    (Institute of Cancer Research)

  • Shazia S. Mahamdallie

    (Institute of Cancer Research)

  • Anne Murray

    (Institute of Cancer Research)

  • Emma Ramsay

    (Institute of Cancer Research)

  • Silvana Del Vecchio Duarte

    (Institute of Cancer Research)

  • Anna Zachariou

    (Institute of Cancer Research)

  • Bianca de Souza

    (Institute of Cancer Research
    Cancer Genetics Unit, Royal Marsden Hospital NHS Foundation Trust)

  • Margaret Warren-Perry

    (Institute of Cancer Research)

  • Anna Elliott

    (Institute of Cancer Research)

  • Alan Davidson

    (Red Cross Children’s Hospital, University of Cape Town)

  • Helen Price

    (Great Western Hospital)

  • Charles Stiller

    (Childhood Cancer Research Group, University of Oxford)

  • Kathy Pritchard-Jones

    (Molecular Haematology and Cancer Biology Unit, Institute of Child Health, University College London)

  • Nazneen Rahman

    (Institute of Cancer Research
    Cancer Genetics Unit, Royal Marsden Hospital NHS Foundation Trust)

Abstract

Wilms tumour is a childhood kidney cancer. Here we identify inactivating CTR9 mutations in 3 of 35 Wilms tumour families, through exome and Sanger sequencing. By contrast, no similar mutations are present in 1,000 population controls (P

Suggested Citation

  • Sandra Hanks & Elizabeth R. Perdeaux & Sheila Seal & Elise Ruark & Shazia S. Mahamdallie & Anne Murray & Emma Ramsay & Silvana Del Vecchio Duarte & Anna Zachariou & Bianca de Souza & Margaret Warren-P, 2014. "Germline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour," Nature Communications, Nature, vol. 5(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5398
    DOI: 10.1038/ncomms5398
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    Cited by:

    1. Zhaoyu Xue & Hongwen Xuan & Kin Lau & Yangzhou Su & Marc Wegener & Kuai Li & Lisa Turner & Marie Adams & Xiaobing Shi & Hong Wen, 2025. "Expression of ENL YEATS domain tumor mutations in nephrogenic or stromal lineage impairs kidney development," Nature Communications, Nature, vol. 16(1), pages 1-22, December.

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