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Balanced activity in basal ganglia projection pathways is critical for contraversive movements

Author

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  • Fatuel Tecuapetla

    (Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown
    Present address: Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Circuito Exterior, S/N, CU, Coyoacán, D.F. México)

  • Sara Matias

    (Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown)

  • Guillaume P. Dugue

    (Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown
    Present address: Ecole Normale Supérieure, CNRS UMR 8197, INSERM U1024, IBENS S4.9, 46 rue d’Ulm, 75005 Paris, France)

  • Zachary F. Mainen

    (Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown)

  • Rui M. Costa

    (Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown)

Abstract

The basal ganglia, and the striatum in particular, have been implicated in the generation of contraversive movements. The striatum projects to downstream basal ganglia nuclei through two main circuits, originating in striatonigral and striatopallidal neurons, and different models postulate that the two pathways can work in opposition or synergistically. Here we show striatonigral and striatopallidal neurons are concurrently active during spontaneous contraversive movements. Furthermore, we show that unilateral optogenetic inhibition of either or both projection pathways disrupts contraversive movements. Consistently, simultaneous activation of both neuron types produces contraversive movements. Still, we also show that imbalanced activity between the pathways can result in opposing movements being driven by each projection pathway. These data show that balanced activity in both striatal projection pathways is critical for the generation of contraversive movements and highlights that imbalanced activity between the two projection pathways can result in opposing motor output.

Suggested Citation

  • Fatuel Tecuapetla & Sara Matias & Guillaume P. Dugue & Zachary F. Mainen & Rui M. Costa, 2014. "Balanced activity in basal ganglia projection pathways is critical for contraversive movements," Nature Communications, Nature, vol. 5(1), pages 1-10, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5315
    DOI: 10.1038/ncomms5315
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    Cited by:

    1. Leslie J. Sibener & Alice C. Mosberger & Tiffany X. Chen & Vivek R. Athalye & James M. Murray & Rui M. Costa, 2025. "Dissociable roles of distinct thalamic circuits in learning reaches to spatial targets," Nature Communications, Nature, vol. 16(1), pages 1-18, December.
    2. Maria Risi & Diletta Cavezza & Giulia Torromino & Anita Capalbo & Xabier Bujanda Cundin & Rosaria Martino & Filomena Grazia Alvino & Attilio Iemolo & Luisa Speranza & Carla Perrone-Capano & Marianna C, 2025. "Cortico-striatal circuit mechanisms drive the effects of D1 dopamine agonists on memory capacity in mice through cAMP/PKA signalling," Nature Communications, Nature, vol. 16(1), pages 1-19, December.
    3. Bernard Bloem & Rafiq Huda & Ken-ichi Amemori & Alex S. Abate & Gayathri Krishna & Anna L. Wilson & Cody W. Carter & Mriganka Sur & Ann M. Graybiel, 2022. "Multiplexed action-outcome representation by striatal striosome-matrix compartments detected with a mouse cost-benefit foraging task," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Sean C. Piantadosi & Elizabeth E. Manning & Brittany L. Chamberlain & James Hyde & Zoe LaPalombara & Nicholas M. Bannon & Jamie L. Pierson & Vijay M. K Namboodiri & Susanne E. Ahmari, 2024. "Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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