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Sema3E/PlexinD1 regulates the migration of hem-derived Cajal-Retzius cells in developing cerebral cortex

Author

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  • Ana Bribián

    (Molecular and Cellular Neurobiotechnology, Institute of Bioengineering of Catalonia (IBEC), Parc Científic de Barcelona
    Universitat de Barcelona
    Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)
    Present address: Laboratorio de Neurobiología del Desarrollo, Hospital Nacional de Parapléjicos, Finca La Peraleda s/n, E-45071 Toledo, Spain)

  • Sara Nocentini

    (Molecular and Cellular Neurobiotechnology, Institute of Bioengineering of Catalonia (IBEC), Parc Científic de Barcelona
    Universitat de Barcelona
    Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED))

  • Franc Llorens

    (Molecular and Cellular Neurobiotechnology, Institute of Bioengineering of Catalonia (IBEC), Parc Científic de Barcelona
    Universitat de Barcelona
    Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)
    Present address: CJD Research group, Neurologische Klinik Robert Koch Street, 40 37075 Göttingen, Germany)

  • Vanessa Gil

    (Molecular and Cellular Neurobiotechnology, Institute of Bioengineering of Catalonia (IBEC), Parc Científic de Barcelona
    Universitat de Barcelona
    Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED))

  • Erik Mire

    (Developmental Biology, Institute of Marseille Luminy, CNRS UMR 6216, University of the Mediterranean, Parc Scientifique de Luminy)

  • Diego Reginensi

    (Molecular and Cellular Neurobiotechnology, Institute of Bioengineering of Catalonia (IBEC), Parc Científic de Barcelona
    Universitat de Barcelona
    Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED))

  • Yutaka Yoshida

    (Cincinnati Children’s Hospital Medical Center)

  • Fanny Mann

    (Developmental Biology, Institute of Marseille Luminy, CNRS UMR 6216, University of the Mediterranean, Parc Scientifique de Luminy)

  • José Antonio del Río

    (Molecular and Cellular Neurobiotechnology, Institute of Bioengineering of Catalonia (IBEC), Parc Científic de Barcelona
    Universitat de Barcelona
    Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED))

Abstract

During the development of the cerebral cortex, Cajal-Retzius (CR) cells settle in the preplate and coordinate the precise growth of the neocortex. Indeed, CR cells migrate tangentially from specific proliferative regions of the telencephalon (for example, the cortical hem (CH)) to populate the entire cortical surface. This is a very finely tuned process regulated by an emerging number of factors that has been sequentially revealed in recent years. However, the putative participation of one of the major families of axon guidance molecules in this process, the Semaphorins, was not explored. Here we show that Semaphorin-3E (Sema3E) is a natural negative regulator of the migration of PlexinD1-positive CR cells originating in the CH. Our results also indicate that Sema3E/PlexinD1 signalling controls the motogenic potential of CR cells in vitro and in vivo. Indeed, absence of Sema3E/PlexinD1 signalling increased the migratory properties of CR cells. This modulation implies negative effects on CXCL12/CXCR4 signalling and increased ADF/Cofilin activity.

Suggested Citation

  • Ana Bribián & Sara Nocentini & Franc Llorens & Vanessa Gil & Erik Mire & Diego Reginensi & Yutaka Yoshida & Fanny Mann & José Antonio del Río, 2014. "Sema3E/PlexinD1 regulates the migration of hem-derived Cajal-Retzius cells in developing cerebral cortex," Nature Communications, Nature, vol. 5(1), pages 1-14, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5265
    DOI: 10.1038/ncomms5265
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