IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v5y2014i1d10.1038_ncomms5246.html
   My bibliography  Save this article

Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase

Author

Listed:
  • Chun-Kan Chen

    (Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California
    Keck School of Medicine, University of Southern California)

  • Catherine Bregere

    (Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California)

  • Jeremy Paluch

    (University of Southern California)

  • Jason F. Lu

    (Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California)

  • Dion K. Dickman

    (University of Southern California)

  • Karen T. Chang

    (Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California
    Keck School of Medicine, University of Southern California)

Abstract

Phosphorylation has emerged as a crucial regulatory mechanism in the nervous system to integrate the dynamic signalling required for proper synaptic development, function and plasticity, particularly during changes in neuronal activity. Here we present evidence that Minibrain (Mnb; also known as Dyrk1A), a serine/threonine kinase implicated in autism spectrum disorder and Down syndrome, is required presynaptically for normal synaptic growth and rapid synaptic vesicle endocytosis at the Drosophila neuromuscular junction (NMJ). We find that Mnb-dependent phosphorylation of Synaptojanin (Synj) is required, in vivo, for complex endocytic protein interactions and to enhance Synj activity. Neuronal stimulation drives Mnb mobilization to endocytic zones and triggers Mnb-dependent phosphorylation of Synj. Our data identify Mnb as a synaptic kinase that promotes efficient synaptic vesicle recycling by dynamically calibrating Synj function at the Drosophila NMJ, and in turn endocytic capacity, to adapt to conditions of high synaptic activity.

Suggested Citation

  • Chun-Kan Chen & Catherine Bregere & Jeremy Paluch & Jason F. Lu & Dion K. Dickman & Karen T. Chang, 2014. "Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase," Nature Communications, Nature, vol. 5(1), pages 1-14, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5246
    DOI: 10.1038/ncomms5246
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms5246
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms5246?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5246. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.