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Systemic regulation of mammalian ageing and longevity by brain sirtuins

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  • Akiko Satoh

    (Washington University School of Medicine, Campus Box 8103, 660 South Euclid Avenue, St Louis, Missouri 63110, USA)

  • Shin-ichiro Imai

    (Washington University School of Medicine, Campus Box 8103, 660 South Euclid Avenue, St Louis, Missouri 63110, USA)

Abstract

Sirtuins have been implicated in the ageing process in a variety of organisms, but their role in mammalian ageing remains somewhat controversial. Here the authors discuss sirtuin proteins in the brain, providing an overview of their physiological functions as well as their implication in mammalian ageing.

Suggested Citation

  • Akiko Satoh & Shin-ichiro Imai, 2014. "Systemic regulation of mammalian ageing and longevity by brain sirtuins," Nature Communications, Nature, vol. 5(1), pages 1-11, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5211
    DOI: 10.1038/ncomms5211
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