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Human B cells induce dendritic cell maturation and favour Th2 polarization by inducing OX-40 ligand

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  • Mohan S. Maddur

    (Institut National de la Santé et de la Recherche Médicale Unité 1138
    Centre de Recherche des Cordeliers, Equipe 16- Immunopathology and Therapeutic Immunointervention, Université Pierre et Marie Curie – Paris 6, UMR S 1138
    Université Paris Descartes, UMR S 1138
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University)

  • Meenu Sharma

    (Institut National de la Santé et de la Recherche Médicale Unité 1138
    Université de Technologie de Compiègne)

  • Pushpa Hegde

    (Institut National de la Santé et de la Recherche Médicale Unité 1138
    Université de Technologie de Compiègne)

  • Emmanuel Stephen-Victor

    (Institut National de la Santé et de la Recherche Médicale Unité 1138
    Centre de Recherche des Cordeliers, Equipe 16- Immunopathology and Therapeutic Immunointervention, Université Pierre et Marie Curie – Paris 6, UMR S 1138)

  • Bali Pulendran

    (Emory Vaccine Center, Yerkes National Primate Research Center, Emory University)

  • Srini V. Kaveri

    (Institut National de la Santé et de la Recherche Médicale Unité 1138
    Centre de Recherche des Cordeliers, Equipe 16- Immunopathology and Therapeutic Immunointervention, Université Pierre et Marie Curie – Paris 6, UMR S 1138
    Université Paris Descartes, UMR S 1138
    International Associated Laboratory IMPACT (Institut National de la Santé et de la Recherche Médicale, France - Indian Council of Medical Research, India), National Institute of Immunohaematology)

  • Jagadeesh Bayry

    (Institut National de la Santé et de la Recherche Médicale Unité 1138
    Centre de Recherche des Cordeliers, Equipe 16- Immunopathology and Therapeutic Immunointervention, Université Pierre et Marie Curie – Paris 6, UMR S 1138
    Université Paris Descartes, UMR S 1138
    International Associated Laboratory IMPACT (Institut National de la Santé et de la Recherche Médicale, France - Indian Council of Medical Research, India), National Institute of Immunohaematology)

Abstract

Dendritic cells (DCs) play a critical role in immune homeostasis by regulating the functions of various immune cells, including T and B cells. Notably, DCs also undergo education on reciprocal signalling by these immune cells and environmental factors. Various reports demonstrated that B cells have profound regulatory functions, although only few reports have explored the regulation of human DCs by B cells. Here we demonstrate that activated but not resting B cells induce maturation of DCs with distinct features to polarize Th2 cells that secrete interleukin (IL)-5, IL-4 and IL-13. B-cell-induced maturation of DCs is contact dependent and implicates signalling of B-cell activation molecules CD69, B-cell-activating factor receptor, and transmembrane activator and calcium-modulating cyclophilin ligand interactor. Mechanistically, differentiation of Th2 cells by B-cell-matured DCs is dependent on OX-40 ligand. Collectively, our results suggest that B cells have the ability to control their own effector functions by enhancing the ability of human DCs to mediate Th2 differentiation.

Suggested Citation

  • Mohan S. Maddur & Meenu Sharma & Pushpa Hegde & Emmanuel Stephen-Victor & Bali Pulendran & Srini V. Kaveri & Jagadeesh Bayry, 2014. "Human B cells induce dendritic cell maturation and favour Th2 polarization by inducing OX-40 ligand," Nature Communications, Nature, vol. 5(1), pages 1-13, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5092
    DOI: 10.1038/ncomms5092
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