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2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

Author

Listed:
  • Jingmei Li

    (Human Genetics, Genome Institute of Singapore
    Saw Swee Hock School of Public Health, National University of Singapore)

  • Linda S. Lindström

    (University of California at San Francisco (UCSF)
    Karolinska Institutet and University Hospital)

  • Jia N. Foo

    (Human Genetics, Genome Institute of Singapore)

  • Sajjad Rafiq

    (Faculty of Medicine, University of Southampton, University Hospital Southampton)

  • Marjanka K. Schmidt

    (Netherlands Cancer Institute
    Netherlands Cancer Institute)

  • Paul D. P. Pharoah

    (Centre for Cancer Genetic Epidemiology, University of Cambridge
    Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Kyriaki Michailidou

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Joe Dennis

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Manjeet K. Bolla

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Qin Wang

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Laura J. Van ‘t Veer

    (Netherlands Cancer Institute)

  • Sten Cornelissen

    (Netherlands Cancer Institute)

  • Emiel Rutgers

    (Netherlands Cancer Institute)

  • Melissa C. Southey

    (Genetic Epidemiology Laboratory, The University of Melbourne)

  • Carmel Apicella

    (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne)

  • Gillian S. Dite

    (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne)

  • John L. Hopper

    (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne
    Graduate School of Public Health, Seoul National University)

  • Peter A. Fasching

    (University Breast Center Franconia, University Hospital Erlangen, Friedrich-Alexander University Erlangen–Nuremberg
    David Geffen School of Medicine, University of California at Los Angeles)

  • Lothar Haeberle

    (University Breast Center Franconia, University Hospital Erlangen, Friedrich-Alexander University Erlangen–Nuremberg)

  • Arif B. Ekici

    (Institute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg)

  • Matthias W. Beckmann

    (University Breast Center Franconia, University Hospital Erlangen, Friedrich-Alexander University Erlangen–Nuremberg)

  • Carl Blomqvist

    (University of Helsinki and Helsinki University Central Hospital)

  • Taru A. Muranen

    (University of Helsinki and Helsinki University Central Hospital)

  • Kristiina Aittomäki

    (University of Helsinki and Helsinki University Central Hospital)

  • Annika Lindblom

    (Karolinska Institutet)

  • Sara Margolin

    (Karolinska Institutet)

  • Arto Mannermaa

    (School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland
    Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland
    Cancer Center, Kuopio University Hospital)

  • Veli-Matti Kosma

    (School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland
    Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland
    Cancer Center, Kuopio University Hospital)

  • Jaana M. Hartikainen

    (School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland
    Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland
    Cancer Center, Kuopio University Hospital)

  • Vesa Kataja

    (School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland
    Cancer Center, Kuopio University Hospital
    Jyväskylä Central Hospital)

  • Georgia Chenevix-Trench

    (QIMR Berghofer Medical Research Institute)

  • kConFab Investigators

    (Peter MacCallum Cancer Center)

  • Kelly-Anne Phillips

    (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne
    University of Melbourne)

  • Sue-Anne McLachlan

    (St Vincent’s Hospital Melbourne)

  • Diether Lambrechts

    (Vesalius Research Center (VRC), VIB
    Laboratory for Translational Genetics, University of Leuven)

  • Bernard Thienpont

    (Vesalius Research Center (VRC), VIB
    Laboratory for Translational Genetics, University of Leuven)

  • Ann Smeets

    (Multidisciplinary Breast Center, University Hospitals Leuven)

  • Hans Wildiers

    (Multidisciplinary Breast Center, University Hospitals Leuven)

  • Jenny Chang-Claude

    (German Cancer Research Center (DKFZ))

  • Dieter Flesch-Janys

    (German Cancer Research Center (DKFZ)
    University Clinic Hamburg-Eppendorf
    Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf)

  • Petra Seibold

    (German Cancer Research Center (DKFZ))

  • Anja Rudolph

    (German Cancer Research Center (DKFZ))

  • Graham G. Giles

    (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne
    Cancer Epidemiology Centre, Cancer Council Victoria)

  • Laura Baglietto

    (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne
    Cancer Epidemiology Centre, Cancer Council Victoria)

  • Gianluca Severi

    (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne
    Cancer Epidemiology Centre, Cancer Council Victoria)

  • Christopher A. Haiman

    (Keck School of Medicine, University of Southern California)

  • Brian E. Henderson

    (University of Hawaii Cancer Center)

  • Fredrick Schumacher

    (Keck School of Medicine, University of Southern California)

  • Loic Le Marchand

    (University of Hawaii Cancer Center)

  • Vessela Kristensen

    (Institute for Cancer Research, Oslo University Hospital
    K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo
    Akershus University Hospital)

  • Grethe I. Grenaker Alnæs

    (Institute for Cancer Research, Oslo University Hospital
    K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo)

  • Anne-Lise Borresen-Dale

    (Institute for Cancer Research, Oslo University Hospital
    K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo)

  • Silje Nord

    (Institute for Cancer Research, Oslo University Hospital
    K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo)

  • Robert Winqvist

    (Laboratory of Cancer Genetics and Tumor Biology, University of Oulu, Oulu University Hospital)

  • Katri Pylkäs

    (Laboratory of Cancer Genetics and Tumor Biology, University of Oulu, Oulu University Hospital)

  • Arja Jukkola-Vuorinen

    (Laboratory of Oncology, Oulu University Hospital, University of Oulu)

  • Mervi Grip

    (Laboratory of Oncology, Oulu University Hospital, University of Oulu)

  • Irene L. Andrulis

    (Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital
    University of Toronto)

  • Julia A. Knight

    (Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital
    Dalla Lana School of Public Health, University of Toronto)

  • Gord Glendon

    (Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital)

  • Sandrine Tchatchou

    (Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital)

  • Peter Devilee

    (Leiden University Medical Center
    Leiden University Medical Center)

  • Robert Tollenaar

    (Leiden University Medical Center)

  • Caroline Seynaeve

    (Erasmus MC Cancer Institute)

  • Maartje Hooning

    (Erasmus MC Cancer Institute)

  • Mieke Kriege

    (Erasmus MC Cancer Institute)

  • Antoinette Hollestelle

    (Erasmus MC Cancer Institute)

  • Ans van den Ouweland

    (Erasmus University Medical Center)

  • Yi Li

    (Human Genetics, Genome Institute of Singapore)

  • Ute Hamann

    (Molecular Genetics of Breast Cancer, DKFZ)

  • Diana Torres

    (Molecular Genetics of Breast Cancer, DKFZ
    Institute of Human Genetics, Pontificia University Javeriana)

  • Hans U. Ulmer

    (Frauenklinik der Stadtklinik Baden-Baden)

  • Thomas Rüdiger

    (Institute of Pathology, Städtisches Klinikum Karlsruhe)

  • Chen-Yang Shen

    (Institute of Biomedical Sciences, Academia Sinica
    College of Public Health, China Medical University)

  • Chia-Ni Hsiung

    (Institute of Biomedical Sciences, Academia Sinica)

  • Pei-Ei Wu

    (Taiwan Biobank, Academia Sinica)

  • Shou-Tung Chen

    (Changhua Christian Hospital)

  • Soo Hwang Teo

    (Cancer Research Initiatives Foundation, Sime Darby Medical Centre
    Breast Cancer Research Unit, Faculty of Medicine, University Malaya Cancer Research Institute, University Malaya)

  • Nur Aishah Mohd Taib

    (Breast Cancer Research Unit, Faculty of Medicine, University Malaya Cancer Research Institute, University Malaya)

  • Cheng Har Yip

    (Breast Cancer Research Unit, Faculty of Medicine, University Malaya Cancer Research Institute, University Malaya)

  • Gwo Fuang Ho

    (Faculty of Medicine, University Malaya)

  • Keitaro Matsuo

    (Faculty of Medical Sciences, Kyushu University)

  • Hidemi Ito

    (Aichi Cancer Center Research Institute)

  • Hiroji Iwata

    (Aichi Cancer Center Hospital)

  • Kazuo Tajima

    (Aichi Cancer Center Research Institute)

  • Daehee Kang

    (Seoul National University College of Medicine
    Seoul National University Graduate School)

  • Ji-Yeob Choi

    (Seoul National University Graduate School)

  • Sue K. Park

    (Seoul National University College of Medicine
    Seoul National University Graduate School)

  • Keun-Young Yoo

    (Seoul National University College of Medicine)

  • Tom Maishman

    (Faculty of Medicine, University of Southampton, University Hospital Southampton)

  • William J. Tapper

    (Faculty of Medicine, University of Southampton, University Hospital Southampton)

  • Alison Dunning

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Mitul Shah

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Robert Luben

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Judith Brown

    (Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Chiea Chuen Khor

    (Human Genetics, Genome Institute of Singapore)

  • Diana M. Eccles

    (Faculty of Medicine, University of Southampton, University Hospital Southampton)

  • Heli Nevanlinna

    (University of Helsinki and Helsinki University Central Hospital)

  • Douglas Easton

    (Centre for Cancer Genetic Epidemiology, University of Cambridge
    Centre for Cancer Genetic Epidemiology, University of Cambridge)

  • Keith Humphreys

    (Karolinska Institutet)

  • Jianjun Liu

    (Human Genetics, Genome Institute of Singapore)

  • Per Hall

    (Karolinska Institutet)

  • Kamila Czene

    (Karolinska Institutet)

Abstract

Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49–2.19); P for trend=1.90 × 10−9). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.

Suggested Citation

  • Jingmei Li & Linda S. Lindström & Jia N. Foo & Sajjad Rafiq & Marjanka K. Schmidt & Paul D. P. Pharoah & Kyriaki Michailidou & Joe Dennis & Manjeet K. Bolla & Qin Wang & Laura J. Van ‘t Veer & Sten Co, 2014. "2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy," Nature Communications, Nature, vol. 5(1), pages 1-9, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5051
    DOI: 10.1038/ncomms5051
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