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Mid-range Ca2+ signalling mediated by functional coupling between store-operated Ca2+ entry and IP3-dependent Ca2+ release

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  • Raphaël Courjaret

    (Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, PO Box 24144)

  • Khaled Machaca

    (Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, PO Box 24144)

Abstract

The versatility and universality of Ca2+ signals stem from the breadth of their spatial and temporal dynamics. Spatially, Ca2+ signalling is well studied in the microdomain scale, close to a Ca2+ channel, and at the whole-cell level. However, little is known about how local Ca2+ signals are regulated to specifically activate spatially distant effectors without a global Ca2+ rise. Here we show that an intricate coupling between the inositol 1,4,5 trisphosphate (IP3) receptor, SERCA pump and store-operated Ca2+ entry (SOCE) allows for efficient mid-range Ca2+ signalling. Ca2+ flowing through SOCE is taken up into the ER lumen by the SERCA pump, only to be re-released by IP3Rs to activate distal Ca2+-activated Cl− channels (CaCCs). This CaCC regulation contributes to setting the membrane potential of the cell. Hence functional coupling between SOCE, SERCA and IP3R limits local Ca2+ diffusion and funnels Ca2+ through the ER lumen to activate a spatially separate Ca2+ effector.

Suggested Citation

  • Raphaël Courjaret & Khaled Machaca, 2014. "Mid-range Ca2+ signalling mediated by functional coupling between store-operated Ca2+ entry and IP3-dependent Ca2+ release," Nature Communications, Nature, vol. 5(1), pages 1-12, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4916
    DOI: 10.1038/ncomms4916
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