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Association analysis identifies new risk loci for non-obstructive azoospermia in Chinese men

Author

Listed:
  • Zhibin Hu

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    School of Public Health, Nanjing Medical University)

  • Zheng Li

    (Shanghai Human Sperm Bank, Renji Hospital, Shanghai Jiao Tong University School of Medicine)

  • Jun Yu

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    Nanjing Medical University)

  • Chao Tong

    (Institute of Preventive Veterinary Medicine, Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, Zhejiang University)

  • Yuan Lin

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    School of Public Health, Nanjing Medical University)

  • Xuejiang Guo

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    Nanjing Medical University)

  • Feng Lu

    (School of Public Health, Nanjing Medical University)

  • Jing Dong

    (School of Public Health, Nanjing Medical University)

  • Yankai Xia

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    School of Public Health, Nanjing Medical University)

  • Yang Wen

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    School of Public Health, Nanjing Medical University)

  • Hao Wu

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    Nanjing Medical University)

  • Honggang Li

    (Family Planning Research Institute, Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology)

  • Yong Zhu

    (Shanghai Human Sperm Bank, Renji Hospital, Shanghai Jiao Tong University School of Medicine)

  • Ping Ping

    (Shanghai Human Sperm Bank, Renji Hospital, Shanghai Jiao Tong University School of Medicine)

  • Xiangfeng Chen

    (Shanghai Human Sperm Bank, Renji Hospital, Shanghai Jiao Tong University School of Medicine)

  • Juncheng Dai

    (School of Public Health, Nanjing Medical University)

  • Yue Jiang

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    School of Public Health, Nanjing Medical University)

  • Shandong Pan

    (School of Public Health, Nanjing Medical University)

  • Peng Xu

    (Jinghua Hospital, Shenyang Dongfang Medical Group)

  • Kailing Luo

    (Reproductive Medical Center, The Second Hospital of Nanning)

  • Qiang Du

    (Shengjing Hospital, China Medical University)

  • Bing Yao

    (Nanjing Jinling Hospital)

  • Ming Liang

    (The Second Affiliated Hospital, Shandong University of Traditional Chinese Medicine)

  • Yaoting Gui

    (Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, FuTian District)

  • Ning Weng

    (Jinghua Hospital, Shenyang Dongfang Medical Group)

  • Hui Lu

    (Shanghai Human Sperm Bank, Renji Hospital, Shanghai Jiao Tong University School of Medicine)

  • Zhuqing Wang

    (Shanghai Human Sperm Bank, Renji Hospital, Shanghai Jiao Tong University School of Medicine)

  • Fengbin Zhang

    (The Women’s Hospital, School of Medicine, Zhejiang University)

  • Xiaobin Zhu

    (Shanghai Human Sperm Bank, Renji Hospital, Shanghai Jiao Tong University School of Medicine)

  • Xiaoyu Yang

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    Center of Clinical Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University)

  • Zhou Zhang

    (Maternal and Child Health Hospital of Shanxi Province)

  • Han Zhao

    (Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University)

  • Chenliang Xiong

    (Family Planning Research Institute, Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology)

  • Hongxia Ma

    (School of Public Health, Nanjing Medical University)

  • Guangfu Jin

    (School of Public Health, Nanjing Medical University)

  • Feng Chen

    (School of Public Health, Nanjing Medical University)

  • Jianfeng Xu

    (Huashan Hospital, Fudan University)

  • Xinru Wang

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    School of Public Health, Nanjing Medical University)

  • Zuomin Zhou

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    Nanjing Medical University)

  • Zi-Jiang Chen

    (Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University)

  • Jiayin Liu

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    Center of Clinical Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University)

  • Hongbing Shen

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    School of Public Health, Nanjing Medical University)

  • Jiahao Sha

    (State Key Laboratory of Reproductive Medicine, Nanjing Medical University
    Nanjing Medical University)

Abstract

Male factor infertility affects one-sixth of couples worldwide, and non-obstructive azoospermia (NOA) is one of the most severe forms. Our previous genome-wide association study (GWAS) identified three susceptibility loci for NOA in Han Chinese men. Here we test promising associations in an extended three-stage validation using 3,608 NOA cases and 5,909 controls to identify additional risk loci. We find strong evidence of three NOA susceptibility loci (P

Suggested Citation

  • Zhibin Hu & Zheng Li & Jun Yu & Chao Tong & Yuan Lin & Xuejiang Guo & Feng Lu & Jing Dong & Yankai Xia & Yang Wen & Hao Wu & Honggang Li & Yong Zhu & Ping Ping & Xiangfeng Chen & Juncheng Dai & Yue Ji, 2014. "Association analysis identifies new risk loci for non-obstructive azoospermia in Chinese men," Nature Communications, Nature, vol. 5(1), pages 1-7, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4857
    DOI: 10.1038/ncomms4857
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