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A population of glomerular glutamatergic neurons controls sensory information transfer in the mouse olfactory bulb

Author

Listed:
  • Roberta Tatti

    (School of Medicine, University of Geneva
    Geneva Neuroscience Center, University of Geneva)

  • Khaleel Bhaukaurally

    (School of Medicine, University of Geneva
    Geneva Neuroscience Center, University of Geneva)

  • Olivier Gschwend

    (School of Medicine, University of Geneva
    Geneva Neuroscience Center, University of Geneva)

  • Rebecca P. Seal

    (School of Medicine, University of Pittsburgh)

  • Robert H. Edwards

    (School of Medicine, University of California)

  • Ivan Rodriguez

    (Geneva Neuroscience Center, University of Geneva
    University of Geneva)

  • Alan Carleton

    (School of Medicine, University of Geneva
    Geneva Neuroscience Center, University of Geneva)

Abstract

In sensory systems, peripheral organs convey sensory inputs to relay networks where information is shaped by local microcircuits before being transmitted to cortical areas. In the olfactory system, odorants evoke specific patterns of sensory neuron activity that are transmitted to output neurons in olfactory bulb (OB) glomeruli. How sensory information is transferred and shaped at this level remains still unclear. Here we employ mouse genetics, 2-photon microscopy, electrophysiology and optogenetics, to identify a novel population of glutamatergic neurons (VGLUT3+) in the glomerular layer of the adult mouse OB as well as several of their synaptic targets. Both peripheral and serotoninergic inputs control VGLUT3+ neurons firing. Furthermore, we show that VGLUT3+ neuron photostimulation in vivo strongly suppresses both spontaneous and odour-evoked firing of bulbar output neurons. In conclusion, we identify and characterize here a microcircuit controlling the transfer of sensory information at an early stage of the olfactory pathway.

Suggested Citation

  • Roberta Tatti & Khaleel Bhaukaurally & Olivier Gschwend & Rebecca P. Seal & Robert H. Edwards & Ivan Rodriguez & Alan Carleton, 2014. "A population of glomerular glutamatergic neurons controls sensory information transfer in the mouse olfactory bulb," Nature Communications, Nature, vol. 5(1), pages 1-16, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4791
    DOI: 10.1038/ncomms4791
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