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Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation

Author

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  • Swathi Srivatsa

    (Institute for Cell and Neurobiology, Center for Anatomy, Charité- Universitätsmedizin Berlin
    Max Planck Institute for Experimental Medicine)

  • Srinivas Parthasarathy

    (Institute for Cell and Neurobiology, Center for Anatomy, Charité- Universitätsmedizin Berlin
    Max Planck Institute for Experimental Medicine)

  • Olga Britanova

    (Institute for Cell and Neurobiology, Center for Anatomy, Charité- Universitätsmedizin Berlin
    Shemyakin and Ovchinnikov Institute for Bioorganic Chemistry RAS)

  • Ingo Bormuth

    (Institute for Cell and Neurobiology, Center for Anatomy, Charité- Universitätsmedizin Berlin)

  • Amber-Lee Donahoo

    (Queensland Brain Institute, School of Biomedical Sciences, The University of Queensland)

  • Susan L. Ackerman

    (Howard Hughes Medical Institute and The Jackson Laboratory)

  • Linda J. Richards

    (Queensland Brain Institute, School of Biomedical Sciences, The University of Queensland)

  • Victor Tarabykin

    (Institute for Cell and Neurobiology, Center for Anatomy, Charité- Universitätsmedizin Berlin)

Abstract

The pyramidal neurons of the mammalian neocortex form two major types of long-range connections—corticocortical and cortico-subcortical. The transcription factors Satb2 and Ctip2 are critical regulators of neuronal cell fate that control interhemispheric versus corticofugal connections respectively. Here, we investigate the axon guidance molecules downstream of Satb2 and Ctip2 that establish these connections. We show that the expression of two Netrin1 receptors- DCC and Unc5C is under direct negative regulation by Satb2 and Ctip2, respectively. Further, we show that the Netrin1–Unc5C/DCC interaction is involved in controlling the interhemispherical projection in a subset of early born, deep layer callosal neurons.

Suggested Citation

  • Swathi Srivatsa & Srinivas Parthasarathy & Olga Britanova & Ingo Bormuth & Amber-Lee Donahoo & Susan L. Ackerman & Linda J. Richards & Victor Tarabykin, 2014. "Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation," Nature Communications, Nature, vol. 5(1), pages 1-15, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4708
    DOI: 10.1038/ncomms4708
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