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Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy

Author

Listed:
  • Ran Namgung

    (Center for Self-assembly and Complexity, Institute for Basic Science
    Pohang University of Science and Technology (POSTECH))

  • Yeong Mi Lee

    (Center for Self-assembly and Complexity, Institute for Basic Science
    Pohang University of Science and Technology (POSTECH))

  • Jihoon Kim

    (Center for Self-assembly and Complexity, Institute for Basic Science
    Pohang University of Science and Technology (POSTECH))

  • Yuna Jang

    (Center for Self-assembly and Complexity, Institute for Basic Science
    Pohang University of Science and Technology (POSTECH))

  • Byung-Heon Lee

    (School of Medicine, Kyungpook National University)

  • In-San Kim

    (School of Medicine, Kyungpook National University
    Biomedical Research Institute, Korea Institute of Science and Technology)

  • Pandian Sokkar

    (Center for Self-assembly and Complexity, Institute for Basic Science
    Pohang University of Science and Technology (POSTECH))

  • Young Min Rhee

    (Center for Self-assembly and Complexity, Institute for Basic Science
    Pohang University of Science and Technology (POSTECH))

  • Allan S. Hoffman

    (University of Washington
    WCU Program, School of Medicine, Kyungpook National University)

  • Won Jong Kim

    (Center for Self-assembly and Complexity, Institute for Basic Science
    Pohang University of Science and Technology (POSTECH))

Abstract

Effective anticancer therapy can be achieved by designing a targeted drug-delivery system with high stability during circulation and efficient uptake by the target tumour cancer cells. We report here a novel nano-assembled drug-delivery system, formed by multivalent host–guest interactions between a polymer–cyclodextrin conjugate and a polymer–paclitaxel conjugate. The multivalent inclusion complexes confer high stability to the nano-assembly, which efficiently delivers paclitaxel into the targeted cancer cells via both passive and active targeting mechanisms. The ester linkages between paclitaxel and the polymer backbone permit efficient release of paclitaxel within the cell by degradation. This novel targeted nano-assembly exhibits significant antitumour activity in a mouse tumour model. The strategy established in this study also provides knowledge for the development of advanced anticancer drug delivery.

Suggested Citation

  • Ran Namgung & Yeong Mi Lee & Jihoon Kim & Yuna Jang & Byung-Heon Lee & In-San Kim & Pandian Sokkar & Young Min Rhee & Allan S. Hoffman & Won Jong Kim, 2014. "Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy," Nature Communications, Nature, vol. 5(1), pages 1-12, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4702
    DOI: 10.1038/ncomms4702
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